A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria

Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl 4 ). Some preselected probiotic bacteria strains have been widely employed in different medical resea...

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Published in:	Environmental science and pollution research international Vol. 28; no. 2; pp. 1555 - 1564
Main Authors:	Allam, Nanis G., El-Sheekh, Mostafa M., Sarhan, Naglaa I., Alfakharany, Ghada S.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021 Springer Nature B.V
Subjects:	Animals Antiinfectives and antibacterials antioxidant activity Antioxidants Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bacteria blood serum Carbon Tetrachloride Cell cycle Chemical and Drug Induced Liver Injury drug therapy Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science fibroblasts Flow cytometry Fumes Growth factors Hepatocytes Hepatotoxicity histopathology Inflammation Lactobacilli Lactobacillus plantarum Leukocytes (mononuclear) Lipid peroxidation Lipids Liver Medical research Mice Peroxidation Plant Extracts Probiotics protective effect Research Article Scavenging Toxicity Transforming growth factor-b Waste Water Technology Water Management Water Pollution Control Hepatoprotective subsp. plantarum DSMZ 2017 Biotherapy Antioxidant CCl Lactobacillus plantarum subsp. plantarum DSMZ 2017 CCl4
ISSN:	0944-1344, 1614-7499, 1614-7499
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Abstract	Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl 4 ). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria ( Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl 4 -induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl 4 -administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl 4 -induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl 4 . In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects.
AbstractList	Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl₄). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria (Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl₄-induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl₄-administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl₄-induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl₄. In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects. Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl4). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria (Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl4-induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl4-administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl4-induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl4. In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects. Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl4). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria (Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl4-induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl4-administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl4-induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl4. In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects.Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl4). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria (Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl4-induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl4-administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl4-induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl4. In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects. Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl ). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria (Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl -induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl -administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl -induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl . In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects. Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl 4 ). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria ( Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl 4 -induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl 4 -administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl 4 -induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl 4 . In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects.
Author	Sarhan, Naglaa I. Alfakharany, Ghada S. El-Sheekh, Mostafa M. Allam, Nanis G.
Author_xml	– sequence: 1 givenname: Nanis G. surname: Allam fullname: Allam, Nanis G. organization: Botany Department, Faculty of Science, Tanta University – sequence: 2 givenname: Mostafa M. orcidid: 0000-0002-2298-6312 surname: El-Sheekh fullname: El-Sheekh, Mostafa M. email: mostafaelsheikh@science.tanta.edu.eg organization: Botany Department, Faculty of Science, Tanta University – sequence: 3 givenname: Naglaa I. surname: Sarhan fullname: Sarhan, Naglaa I. organization: Histology Department, Faculty of Medicine, Tanta University – sequence: 4 givenname: Ghada S. surname: Alfakharany fullname: Alfakharany, Ghada S. organization: Botany Department, Faculty of Science, Tanta University
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Snippet	Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to...
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SubjectTerms	Animals Antiinfectives and antibacterials antioxidant activity Antioxidants Apoptosis Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bacteria blood serum Carbon Tetrachloride Cell cycle Chemical and Drug Induced Liver Injury drug therapy Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science fibroblasts Flow cytometry Fumes Growth factors Hepatocytes Hepatotoxicity histopathology Inflammation Lactobacilli Lactobacillus plantarum Leukocytes (mononuclear) Lipid peroxidation Lipids Liver Medical research Mice Peroxidation Plant Extracts Probiotics protective effect Research Article Scavenging Toxicity Transforming growth factor-b Waste Water Technology Water Management Water Pollution Control
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Title	A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria
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