A new trend in the medication of hepatocyte cytoxicity in mice: protective role of probiotic bacteria

Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl 4 ). Some preselected probiotic bacteria strains have been widely employed in different medical resea...

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Bibliographic Details
Published in:Environmental science and pollution research international Vol. 28; no. 2; pp. 1555 - 1564
Main Authors: Allam, Nanis G., El-Sheekh, Mostafa M., Sarhan, Naglaa I., Alfakharany, Ghada S.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021
Springer Nature B.V
Subjects:
Animals
Antiinfectives and antibacterials
antioxidant activity
Antioxidants
Apoptosis
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bacteria
blood serum
Carbon Tetrachloride
Cell cycle
Chemical and Drug Induced Liver Injury
drug therapy
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
fibroblasts
Flow cytometry
Fumes
Growth factors
Hepatocytes
Hepatotoxicity
histopathology
Inflammation
Lactobacilli
Lactobacillus plantarum
Leukocytes (mononuclear)
Lipid peroxidation
Lipids
Liver
Medical research
Mice
Peroxidation
Plant Extracts
Probiotics
protective effect
Research Article
Scavenging
Toxicity
Transforming growth factor-b
Waste Water Technology
Water Management
Water Pollution Control
Hepatoprotective
subsp. plantarum DSMZ 2017
Biotherapy
Antioxidant
CCl
Lactobacillus plantarum subsp. plantarum DSMZ 2017
CCl4
ISSN:0944-1344, 1614-7499, 1614-7499
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Summary:Liver toxicity is affected by several factors, including certain medications, fumes emission from factories, materials used in industries, and exposure to chemicals such as carbon tetrachloride (CCl 4 ). Some preselected probiotic bacteria strains have been widely employed in different medical researches due to their antioxidant, anticancer, antimicrobial, anti-inflammatory characters, and hepatoprotective factor. The present study was aimed to evaluate the protective role of probiotic bacteria ( Lactobacillus plantarum DSMZ 20174) and their ameliorative effects against CCl 4 -induced hepatotoxicity in mice. The cell cycle of hepatocytes and the expression of transforming growth factor-β (TGF-β) were assessed by flow cytometry as indicators for apoptosis. The antioxidant activity of probiotic bacteria was estimated by measuring lipid peroxidation (LPO) and scavenging 2,2-diphenyl-1-picryl-hydrazyl (DPPH). The results showed that the treatment of CCl 4 -administered mice by supernatant from Lactobacillus plantarum DSMZ 20174 induced an amelioration in CCl 4 -induced increases in serum activity of the liver enzymes and decreases in LPO and DPPH. After treatment with probiotics, the liver histopathological studies showed abundant infiltration and accumulation of mononuclear cells and fibroblast, indicating a positive effect ameliorating the damage previously induced by CCl 4 . In sum, the results of the present work indicate the protective effects of Lactobacillus plantarum against hepatotoxicity through antioxidant effects.
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ISSN:0944-1344
1614-7499
1614-7499
DOI:10.1007/s11356-020-10420-z