Benzo[a]pyrene—Environmental Occurrence, Human Exposure, and Mechanisms of Toxicity

Benzo[a]pyrene (B[a]P) is the main representative of polycyclic aromatic hydrocarbons (PAHs), and has been repeatedly found in the air, surface water, soil, and sediments. It is present in cigarette smoke as well as in food products, especially when smoked and grilled. Human exposure to B[a]P is the...

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Vydané v:International journal of molecular sciences Ročník 23; číslo 11; s. 6348
Hlavní autori: Bukowska, Bożena, Mokra, Katarzyna, Michałowicz, Jaromir
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 06.06.2022
MDPI
Predmet:
Air pollution
Animals
Benzo(a)pyrene - toxicity
Carcinogens
Coal
COVID-19
Cytochrome P-450 Enzyme System - genetics
DNA Adducts
Humans
Hydrocarbons
Indoor air quality
Industrial plant emissions
Lung cancer
Molecular weight
Outdoor air quality
Ovaries
Pandemics
Polycyclic Aromatic Hydrocarbons - metabolism
Polycyclic Aromatic Hydrocarbons - toxicity
Review
China
genotoxicity
metabolism
benzo[a]pyrene
polycyclic aromatic hydrocarbons
carcinogenicity
ISSN:1422-0067, 1661-6596, 1422-0067
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Popis
Shrnutí:Benzo[a]pyrene (B[a]P) is the main representative of polycyclic aromatic hydrocarbons (PAHs), and has been repeatedly found in the air, surface water, soil, and sediments. It is present in cigarette smoke as well as in food products, especially when smoked and grilled. Human exposure to B[a]P is therefore common. Research shows growing evidence concerning toxic effects induced by this substance. This xenobiotic is metabolized by cytochrome P450 (CYP P450) to carcinogenic metabolite: 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), which creates DNA adducts, causing mutations and malignant transformations. Moreover, B[a]P is epigenotoxic, neurotoxic, and teratogenic, and exhibits pro-oxidative potential and causes impairment of animals’ fertility. CYP P450 is strongly involved in B[a]P metabolism, and it is simultaneously expressed as a result of the association of B[a]P with aromatic hydrocarbon receptor (AhR), playing an essential role in the cancerogenic potential of various xenobiotics. In turn, polymorphism of CYP P450 genes determines the sensitivity of the organism to B[a]P. It was also observed that B[a]P facilitates the multiplication of viruses, which may be an additional problem with the widespread COVID-19 pandemic. Based on publications mainly from 2017 to 2022, this paper presents the occurrence of B[a]P in various environmental compartments and human surroundings, shows the exposure of humans to this substance, and describes the mechanisms of its toxicity.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 14
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23116348