Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy

Epstein-Barr virus (EBV) infects ≈ 95% of the adult population. The factors that confer protection in the remaining ≈ 5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 yea...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Journal of virology Ročník 87; číslo 11; s. 6526
Hlavní autori: Durovic, Bojana, Gasser, Olivier, Gubser, Patrick, Sigle, Jörg, Hirsch, Hans H, Stern, Martin, Buser, Andreas, Hess, Christoph
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.06.2013
Predmet:
Aged
Cohort Studies
Disease Resistance
Epstein-Barr Virus Infections - genetics
Epstein-Barr Virus Infections - immunology
Epstein-Barr Virus Infections - virology
Female
Genotype
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - immunology
Herpesvirus 4, Human - physiology
HLA-B Antigens - genetics
HLA-B Antigens - immunology
HLA-C Antigens - genetics
HLA-C Antigens - immunology
Humans
Male
Middle Aged
Tonsillectomy
ISSN:1098-5514, 1098-5514
On-line prístup:Zistit podrobnosti o prístupe
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Epstein-Barr virus (EBV) infects ≈ 95% of the adult population. The factors that confer protection in the remaining ≈ 5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 years. Analyses of HLA genotypes revealed an association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4 alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more often than EBV-positive donors.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1098-5514
1098-5514
DOI:10.1128/JVI.00169-13