Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications

The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms ind...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical science (1979) Jg. 131; H. 13; S. 1405
Hauptverfasser:	Lucas-Herald, Angela K, Alves-Lopes, Rheure, Montezano, Augusto C, Ahmed, S Faisal, Touyz, Rhian M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.07.2017
Schlagworte:	Androgens - physiology Apoptosis - physiology Cardiovascular Diseases - drug therapy Cardiovascular Physiological Phenomena - genetics Cardiovascular System - metabolism DNA - metabolism Genomics Humans Kidney - physiology Penile Erection - physiology Reactive Oxygen Species - metabolism Receptors, Androgen - metabolism Testosterone - physiology Testosterone - therapeutic use androgen receptor cardiovascular genomic non-genomic
ISSN:	1470-8736, 1470-8736
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function.
AbstractList	The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function. The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca2+ mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function.The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca2+ mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function.
Author	Ahmed, S Faisal Alves-Lopes, Rheure Montezano, Augusto C Lucas-Herald, Angela K Touyz, Rhian M
Author_xml	– sequence: 1 givenname: Angela K surname: Lucas-Herald fullname: Lucas-Herald, Angela K organization: Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, U.K – sequence: 2 givenname: Rheure surname: Alves-Lopes fullname: Alves-Lopes, Rheure organization: Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, U.K – sequence: 3 givenname: Augusto C surname: Montezano fullname: Montezano, Augusto C organization: Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, U.K – sequence: 4 givenname: S Faisal surname: Ahmed fullname: Ahmed, S Faisal organization: Developmental Endocrinology Research Group, Queen Elizabeth University Hospital Campus, 1345 Govan Road, Glasgow G51 4TF, U.K – sequence: 5 givenname: Rhian M surname: Touyz fullname: Touyz, Rhian M email: Rhian.touyz@glasgow.ac.uk organization: Institute of Cardiovascular and Medical Sciences, British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow G12 8TA, U.K. Rhian.touyz@glasgow.ac.uk
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28645930$$D View this record in MEDLINE/PubMed
BookMark	eNpNUD1PwzAQtVARLYWFH4A8sgTOdto4bKiCglSJAZjDxb6AkWOXOEHqvyeIIqEb3rt7H8Mds0mIgRg7E3ApIJdXqycJogAo4YDNRF5Apgu1nPzjU3ac0geAVOMcsanUy3xRKpix1zWF2DrDMVg-9mZv-52ahkyfeGx-pC6O98Rd4P07cYOddfELkxk8djztUk_tNTfeBWfQc9du_Uh6F0M6YYcN-kSne5yzl7vb59V9tnlcP6xuNpnJ87zPFNaWCmNAq5osllYprQmsIGig1EIi6YLqWmKBYFCTLZewkOVC5KhIWjlnF7-92y5-DpT6qnXJkPcYKA6pEqVQaswoPVrP99ahbslW28612O2qv6_Ib3nwZm8
CitedBy_id	crossref_primary_10_3390_nu17061013 crossref_primary_10_1097_HJH_0000000000002632 crossref_primary_10_1002_rmb2_12472 crossref_primary_10_1016_j_lfs_2020_118584 crossref_primary_10_1093_cvr_cvab241 crossref_primary_10_1111_nyas_15211 crossref_primary_10_1007_s00210_024_03019_5 crossref_primary_10_1016_j_beem_2025_102000 crossref_primary_10_1111_obr_13429 crossref_primary_10_3390_molecules29010097 crossref_primary_10_1016_j_beem_2025_102004 crossref_primary_10_1080_17446651_2022_2144834 crossref_primary_10_1016_j_vph_2022_107001 crossref_primary_10_1016_j_steroids_2019_02_011 crossref_primary_10_1080_10715762_2022_2038789 crossref_primary_10_3390_antiox8080288 crossref_primary_10_1096_fj_202002526RR crossref_primary_10_1002_jbt_22658 crossref_primary_10_1016_j_atherosclerosis_2023_117282 crossref_primary_10_3389_fendo_2019_00622 crossref_primary_10_1016_j_steroids_2019_108509 crossref_primary_10_1371_journal_pone_0213351 crossref_primary_10_3389_fphys_2021_667961 crossref_primary_10_3390_ijms22168776 crossref_primary_10_1186_s12886_022_02585_7 crossref_primary_10_3390_ijms25094652 crossref_primary_10_1007_s13410_021_01002_x crossref_primary_10_3390_ijms23084404 crossref_primary_10_1016_j_bbamcr_2022_119357 crossref_primary_10_1186_s13293_020_00323_6 crossref_primary_10_1016_j_yfrne_2021_100926 crossref_primary_10_1210_endrev_bnaf005 crossref_primary_10_3389_fendo_2021_648141 crossref_primary_10_1007_s12265_019_09939_5 crossref_primary_10_1172_JCI169085 crossref_primary_10_3390_biom15091284 crossref_primary_10_1016_j_mce_2021_111461 crossref_primary_10_1016_j_molmet_2018_03_001 crossref_primary_10_1007_s12576_017_0590_4 crossref_primary_10_1016_j_cjca_2022_09_018 crossref_primary_10_1159_000504670 crossref_primary_10_1161_ATVBAHA_125_322092 crossref_primary_10_14814_phy2_14088 crossref_primary_10_1016_j_brainres_2018_12_030 crossref_primary_10_3390_ijms232415555 crossref_primary_10_1016_j_jsbmb_2019_105496 crossref_primary_10_1161_HYPERTENSIONAHA_119_13080 crossref_primary_10_23876_j_krcp_20_013 crossref_primary_10_1016_j_mce_2017_12_010 crossref_primary_10_1186_s13293_020_00309_4 crossref_primary_10_1111_bph_14951 crossref_primary_10_1111_andr_12876 crossref_primary_10_1038_s41598_023_46424_1 crossref_primary_10_1007_s11154_018_9449_0 crossref_primary_10_1016_S2213_8587_24_00199_2 crossref_primary_10_1007_s40618_020_01409_z crossref_primary_10_1016_j_mce_2020_110801 crossref_primary_10_3390_cells14060467 crossref_primary_10_3390_ijms24065884 crossref_primary_10_1002_cbin_11768 crossref_primary_10_1093_eurheartj_ehac112 crossref_primary_10_1515_mr_2024_0012 crossref_primary_10_1093_nutrit_nuad003 crossref_primary_10_1016_j_mad_2021_111523 crossref_primary_10_1113_JP287288 crossref_primary_10_3390_ijms23020935 crossref_primary_10_3390_medicina56110606 crossref_primary_10_1016_j_exger_2023_112104 crossref_primary_10_1007_s00359_017_1236_y crossref_primary_10_3390_diagnostics15131682 crossref_primary_10_1038_s41388_021_01874_7
ContentType	Journal Article
Copyright	2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
Copyright_xml	– notice: 2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1042/CS20170090
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Medicine
EISSN	1470-8736
ExternalDocumentID	28645930
Genre	Journal Article Review
GrantInformation_xml	– fundername: Medical Research Council grantid: MR/N003403/1 – fundername: British Heart Foundation grantid: RG/13/7/30099
GroupedDBID	--- 0R~ 29B 2WC 4.4 5GY 5RE 6J9 ABCQX ABJNI ACGFO ACGFS ADBBV AEGXH AENEX AIAGR AIZAD ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DU5 E3Z EBD EBS ECM EIF EJD EMOBN F5P GX1 H13 HZ~ L7B MV1 NPM NTEUP O9- P2P P6G RHI RPO SV3 TR2 WH7 7X8
ID	FETCH-LOGICAL-c444t-3abde7cc083beda9d3388e0d1e0f09812ae87ebb2a7a0ca8ed960529514a3e2d2
IEDL.DBID	7X8
ISICitedReferencesCount	91
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000405988900003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1470-8736
IngestDate	Thu Jul 10 23:01:54 EDT 2025 Mon Jul 21 05:50:41 EDT 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	13
Keywords	androgen receptor cardiovascular genomic non-genomic
Language	English
License	2017 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c444t-3abde7cc083beda9d3388e0d1e0f09812ae87ebb2a7a0ca8ed960529514a3e2d2
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
OpenAccessLink	https://pubmed.ncbi.nlm.nih.gov/PMC5736922
PMID	28645930
PQID	1913396038
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_1913396038 pubmed_primary_28645930
PublicationCentury	2000
PublicationDate	2017-07-01
PublicationDateYYYYMMDD	2017-07-01
PublicationDate_xml	– month: 07 year: 2017 text: 2017-07-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Clinical science (1979)
PublicationTitleAlternate	Clin Sci (Lond)
PublicationYear	2017
SSID	ssj0023232
Score	2.5105257
SecondaryResourceType	review_article
Snippet	The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1405
SubjectTerms	Androgens - physiology Apoptosis - physiology Cardiovascular Diseases - drug therapy Cardiovascular Physiological Phenomena - genetics Cardiovascular System - metabolism DNA - metabolism Genomics Humans Kidney - physiology Penile Erection - physiology Reactive Oxygen Species - metabolism Receptors, Androgen - metabolism Testosterone - physiology Testosterone - therapeutic use
Title	Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications
URI	https://www.ncbi.nlm.nih.gov/pubmed/28645930 https://www.proquest.com/docview/1913396038
Volume	131
WOSCitedRecordID	wos000405988900003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA7qRHzxfpk3IvgaljZZ2_giMpw-uDFQYW81V9lLO9fp7_ekzbw8CIIvhbYU0uQk-U6-75yD0IXwcrWuc4SZhBHOEkqUygThPHWRcomNXB0ofJ8Oh9l4LEbhwK0KssrFmlgv1KbU_oy8A34FYwC3WXY1fSW-apRnV0MJjWXUYgBlvKQrHX-yCAAW6gJlEU8pzHpPUzbpSXnc6T3EPnMMFfR3aFlvMf3N_zZuC20EcImvG2vYRku22EFrg0Cf76LnW1tHIWNZGAx-P3kJ90HVgUvnX81KeF7hSYEBHWL9Q7GKm9TPl3gRUokn3zTpe-ipf_PYuyOhxALRnPM5YVIZm2oNQExZI4UBjzWz1ESWOipg85c2S61SsUwl1TKzBv7Sc4MRl8zGJt5HK9Bce4iw6kaZxy9p12huRQK4E-CVYEZH1Gjl2uh80Xc5mLDnJWRhy7cq_-q9NjpoBiCfNrk28jjz2W4YPfrD18do3Q9qI6Y9QS0HE9ieolX9Pp9Us7PaNuA6HA0-ACRgxQc
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genomic+and+non-genomic+effects+of+androgens+in+the+cardiovascular+system%3A+clinical+implications&rft.jtitle=Clinical+science+%281979%29&rft.au=Lucas-Herald%2C+Angela+K&rft.au=Alves-Lopes%2C+Rheure&rft.au=Montezano%2C+Augusto+C&rft.au=Ahmed%2C+S+Faisal&rft.date=2017-07-01&rft.eissn=1470-8736&rft.volume=131&rft.issue=13&rft.spage=1405&rft_id=info:doi/10.1042%2FCS20170090&rft_id=info%3Apmid%2F28645930&rft_id=info%3Apmid%2F28645930&rft.externalDocID=28645930
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1470-8736&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1470-8736&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1470-8736&client=summon