High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs

High-throughput RNA sequencing methods coupled with specialized bioinformatic analyses have recently uncovered tens of thousands of unique circular (circ)RNAs, but their complete sequences, genes of origin and functions are largely unknown. Given that circRNAs lack free ends and are thus relatively...

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Vydáno v:	Nucleic acids research Ročník 45; číslo 12; s. e116
Hlavní autoři:	Panda, Amaresh C., De, Supriyo, Grammatikakis, Ioannis, Munk, Rachel, Yang, Xiaoling, Piao, Yulan, Dudekula, Dawood B., Abdelmohsen, Kotb, Gorospe, Myriam
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 07.07.2017
Témata:	Animals Base Sequence Cell Line Computational Biology Exons Exoribonucleases - chemistry HeLa Cells High-Throughput Nucleotide Sequencing Humans Introns Methods Online Mice Molecular Sequence Annotation Myoblasts - cytology Myoblasts - metabolism Poly A - genetics Poly A - metabolism Polyadenylation RNA - genetics RNA - isolation & purification RNA - metabolism RNA Cleavage RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism
ISSN:	0305-1048, 1362-4962, 1362-4962
On-line přístup:	Získat plný text
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