Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica

Autoantibody specific for the aquaporin-4 astrocytic water channel is restricted to serum and CSF of patients with neuromyelitis optica (NMO) and related CNS inflammatory demyelinating disorders (relapsing optic neuritis and longitudinally extensive transverse myelitis). NMO-typical lesions are dist...

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Veröffentlicht in:	Neurology Jg. 69; H. 24; S. 2221
Hauptverfasser:	Hinson, S R, Pittock, S J, Lucchinetti, C F, Roemer, S F, Fryer, J P, Kryzer, T J, Lennon, V A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 11.12.2007
Schlagworte:	Animals Aquaporin 4 - immunology Aquaporin 4 - metabolism Binding Sites, Antibody Cell Line Endocytosis - immunology Extracellular Fluid - immunology Extracellular Fluid - metabolism Humans Immunoglobulin G - metabolism Mice Neuromyelitis Optica - immunology Neuromyelitis Optica - metabolism Neuromyelitis Optica - pathology Protein Binding - immunology
ISSN:	1526-632X, 1526-632X
Online-Zugang:	Weitere Angaben
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