Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples

Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent‐free and cost‐effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the...

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Bibliographic Details
Published in:Journal of biophotonics Vol. 7; no. 3-4; pp. 189 - 199
Main Authors: Hands, James R., Dorling, Konrad M., Abel, Peter, Ashton, Katherine M., Brodbelt, Andrew, Davis, Charles, Dawson, Timothy, Jenkinson, Michael D., Lea, Robert W., Walker, Carol, Baker, Matthew J.
Format: Journal Article
Language:English
Published: Berlin WILEY-VCH Verlag 01.04.2014
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
ATR-FTIR
Brain Neoplasms - blood
Brain Neoplasms - diagnosis
Brain tumors
cancer
Early Detection of Cancer
Female
filtrate
Fourier transforms
glioma
Glioma - blood
Glioma - diagnosis
Humans
infrared
Male
Mass Screening - methods
Middle Aged
rapid
Reproducibility of Results
Sensitivity and Specificity
serum
spectroscopy
Spectroscopy, Fourier Transform Infrared - methods
Young Adult
filtrate
ATR-FTIR
spectroscopy
rapid
glioma
cancer
infrared
serum
ISSN:1864-063X, 1864-0648, 1864-0648
Online Access:Get full text
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Summary:Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent‐free and cost‐effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR‐FTIR spectral data combined with a RBF‐SVM for the diagnosis of gliomas (high‐grade and low‐grade) from non‐cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Bibliography:ark:/67375/WNG-2HMVGLT8-Q
istex:BA1CCF266AA0BFD73DE6CA3F37EF55BD83CC93C6
ArticleID:JBIO201300149
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1864-063X
1864-0648
1864-0648
DOI:10.1002/jbio.201300149