Association between metabolic syndrome and risk of incident dementia in UK Biobank

INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia....

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Veröffentlicht in:Alzheimer's & dementia Jg. 20; H. 1; S. 447 - 458
Hauptverfasser: Qureshi, Danial, Collister, Jennifer, Allen, Naomi E., Kuźma, Elżbieta, Littlejohns, Thomas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States John Wiley & Sons, Inc 01.01.2024
John Wiley and Sons Inc
Schlagworte:
Alzheimer's disease
Apolipoproteins
Biobanks
Biological Specimen Banks
Blood pressure
Cholesterol
Codes
cohort studies
Dementia
Dementia - complications
Dementia - epidemiology
Density
Diabetes
Disease
Exercise
follow‐up studies
Genetic susceptibility
Genetics
Glucose
Health risk assessment
Hospitals
Humans
Incidence
Interactive computer systems
Lipids
longitudinal
Longitudinal studies
Males
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - epidemiology
Prospective Studies
Questionnaires
Risk
Risk Factors
Sociodemographics
Triglycerides
UK Biobank
England
Scotland
United Kingdom > UK
Wales
metabolic syndrome
follow-up studies
risk factors
UK biobank
cohort studies
dementia
longitudinal
incidence
ISSN:1552-5260, 1552-5279, 1552-5279
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Zusammenfassung:INTRODUCTION The association between metabolic syndrome (MetS) and incident dementia remains inconclusive. METHODS In 176,249 dementia‐free UK Biobank participants aged ≥60 years at baseline, Cox proportional‐hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high‐density lipoprotein cholesterol. RESULTS Over 15 years of follow‐up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow‐up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein‐E (APOE)‐ε4 non‐carriers. DISCUSSION In this large population‐based prospective cohort, MetS was associated with an increased risk of dementia. Highlights MetS was associated with a 12% increased risk of incident all‐cause dementia. Associations remained similar after restricting the analysis to those with longer follow‐up. The presence of four or five MetS components was significantly associated with dementia. Stronger associations were observed in those with a low genetic risk for dementia.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.13439