Gene-targeted analysis of copy number variants identifies 3 novel associations with coronary heart disease traits

Copy number variants (CNVs) are a major form of genomic variation, which may be implicated in complex disease phenotypes. However, investigation of the role of CNVs in coronary heart disease (CHD) traits has been limited. We examined the use of the cnvHap algorithm for CNV detection, using data for...

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Veröffentlicht in:	Circulation. Cardiovascular genetics Jg. 5; H. 5; S. 555
Hauptverfasser:	Costelloe, Seán J, El-Sayed Moustafa, Julia S, Drenos, Fotios, Palmen, Jutta, Li, Qiao, Qiao, Li, Whiting, Stephen, Thomas, Michael, Kivimaki, Mika, Kumari, Meena, Hingorani, Aroon D, Tzoulaki, Ioanna, Järvelin, Marjo-Riitta, Marjo-Riitta, Järvelin, Ruokonen, Aimo, Aimo, Ruokonen, Hartikainen, Anna-Liisa, Pouta, Anneli, Walters, Robin G, Blakemore, Alexandra I F, Humphries, Steve E, Coin, Lachlan J M, Talmud, Philippa J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2012
Schlagworte:	Algorithms Apolipoprotein A-I - genetics Apolipoprotein A-I - metabolism Apolipoproteins B - genetics Apolipoproteins B - metabolism Cohort Studies Coronary Disease - genetics DNA Copy Number Variations Genome, Human Genotype Humans Interleukin-6 - genetics Interleukin-6 - metabolism Phenotype Polymorphism, Single Nucleotide Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
ISSN:	1942-3268, 1942-3268
Online-Zugang:	Weitere Angaben
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