Association between insomnia and the incidence of myocardial infarction: A systematic review and meta‐analysis

Background Insomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI. Methods PubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and...

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Published in:Clinical cardiology (Mahwah, N.J.) Vol. 46; no. 4; pp. 376 - 385
Main Authors: Dean, Yomna E., Shebl, Mohamed A., Rouzan, Samah S., Bamousa, Bdoor Ahmed A, Talat, Nesreen Elsayed, Ansari, Sana Afreen, Tanas, Yousef, Aslam, Muaaz, Gebril, Sara, Sbitli, Taher, Eweis, Ramy, Shahid, Rameen, Salem, Amr, Abdelaziz, Heba Ahmed, Shah, Jaffer, Hasan, Walaa, Hakim, Diaa, Aiash, Hani
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 01.04.2023
John Wiley and Sons Inc
Subjects:
Body mass index
Cardiovascular disease
Chronic obstructive pulmonary disease
Diabetes
Heart attacks
Hormones
Humans
Hypertension
Incidence
Insomnia
Meta-analysis
myocardial infarction
Myocardial Infarction - epidemiology
Observational studies
Review
Reviews
Risk Factors
Sleep
Sleep disorders
Sleep Initiation and Maintenance Disorders - epidemiology
STEMI
Vein & artery diseases
STEMI
sleep disorders
myocardial infarction
insomnia
ISSN:0160-9289, 1932-8737, 1932-8737
Online Access:Get full text
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Summary:Background Insomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI. Methods PubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among insomniacs were included. Revman software version 5.4 was used for the analysis. Results Our pooled analysis showed a significant association between insomnia and the incidence of MI compared with noninsomniacs (relative risk [RR] = 1.69, 95% confidence interval [CI] = 1.41–2.02, p < .00001). Per sleep duration, we detected the highest association between ≤5 h of sleep, and MI incidence compared to 7−8 h of sleep (RR = 1.56, 95% CI = 1.41–1.73). Disorders of initiating and maintaining sleep were associated with increased MI incidence (RR = 1.13, 95% CI = 1.04–1.23, p = .003). However, subgroup analysis of nonrestorative sleep and daytime dysfunction showed an insignificant association with MI among both groups (RR = 1.06, 95% CI = 0.91–1.23, p = .46). Analysis of age, follow‐up duration, sex, and comorbidities showed a significant association in insomniacs. Conclusion Insomnia and ≤5 h of sleep are highly associated with increased incidence of MI; an association comparable to that of other MI risk factors and as such, it should be considered as a risk factor for MI and to be incorporated into MI prevention guidelines.
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ISSN:0160-9289
1932-8737
1932-8737
DOI:10.1002/clc.23984