Association between insomnia and the incidence of myocardial infarction: A systematic review and meta‐analysis

Background Insomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI. Methods PubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and...

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Vydané v:Clinical cardiology (Mahwah, N.J.) Ročník 46; číslo 4; s. 376 - 385
Hlavní autori: Dean, Yomna E., Shebl, Mohamed A., Rouzan, Samah S., Bamousa, Bdoor Ahmed A, Talat, Nesreen Elsayed, Ansari, Sana Afreen, Tanas, Yousef, Aslam, Muaaz, Gebril, Sara, Sbitli, Taher, Eweis, Ramy, Shahid, Rameen, Salem, Amr, Abdelaziz, Heba Ahmed, Shah, Jaffer, Hasan, Walaa, Hakim, Diaa, Aiash, Hani
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States John Wiley & Sons, Inc 01.04.2023
John Wiley and Sons Inc
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ISSN:0160-9289, 1932-8737, 1932-8737
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Shrnutí:Background Insomnia has been closely associated with cardiovascular disease (CVD) including myocardial infarction (MI). Our study aims to assess the eligibility of insomnia as a potential risk factor for MI. Methods PubMed, Scopus, and Web of Science were searched using terms; such as “Insomnia” and “MI.” Only observational controlled studies with data on the incidence of MI among insomniacs were included. Revman software version 5.4 was used for the analysis. Results Our pooled analysis showed a significant association between insomnia and the incidence of MI compared with noninsomniacs (relative risk [RR] = 1.69, 95% confidence interval [CI] = 1.41–2.02, p < .00001). Per sleep duration, we detected the highest association between ≤5 h of sleep, and MI incidence compared to 7−8 h of sleep (RR = 1.56, 95% CI = 1.41–1.73). Disorders of initiating and maintaining sleep were associated with increased MI incidence (RR = 1.13, 95% CI = 1.04–1.23, p = .003). However, subgroup analysis of nonrestorative sleep and daytime dysfunction showed an insignificant association with MI among both groups (RR = 1.06, 95% CI = 0.91–1.23, p = .46). Analysis of age, follow‐up duration, sex, and comorbidities showed a significant association in insomniacs. Conclusion Insomnia and ≤5 h of sleep are highly associated with increased incidence of MI; an association comparable to that of other MI risk factors and as such, it should be considered as a risk factor for MI and to be incorporated into MI prevention guidelines.
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ISSN:0160-9289
1932-8737
1932-8737
DOI:10.1002/clc.23984