RNAi: antiviral therapy against dengue virus

Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is a...

Full description

Saved in:
Bibliographic Details
Published in:Asian Pacific journal of tropical biomedicine Vol. 3; no. 3; p. 232
Main Authors: Idrees, Sobia, Ashfaq, Usman A
Format: Journal Article
Language:English
Published: China 01.03.2013
Subjects:
Animals
Dengue - therapy
Dengue Virus - genetics
Humans
RNA Interference
RNA, Small Interfering - genetics
RNA, Small Interfering - therapeutic use
RNA interference
Small interference RNA
Dengue haemorrhagic fever
Dengue virus
ISSN:2221-1691
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2221-1691
DOI:10.1016/S2221-1691(13)60057-X