RNAi: antiviral therapy against dengue virus

Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is a...

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Vydáno v:Asian Pacific journal of tropical biomedicine Ročník 3; číslo 3; s. 232
Hlavní autoři: Idrees, Sobia, Ashfaq, Usman A
Médium: Journal Article
Jazyk:angličtina
Vydáno: China 01.03.2013
Témata:
Animals
Dengue - therapy
Dengue Virus - genetics
Humans
RNA Interference
RNA, Small Interfering - genetics
RNA, Small Interfering - therapeutic use
RNA interference
Small interference RNA
Dengue haemorrhagic fever
Dengue virus
ISSN:2221-1691
On-line přístup:Zjistit podrobnosti o přístupu
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Popis
Shrnutí:Dengue virus infection has become a global threat affecting around 100 countries in the world. Currently, there is no licensed antiviral agent available against dengue. Thus, there is a strong need to develop therapeutic strategies that can tackle this life threatening disease. RNA interference is an important and effective gene silencing process which degrades targeted RNA by a sequence specific process. Several studies have been conducted during the last decade to evaluate the efficiency of siRNA in inhibiting dengue virus replication. This review summarizes siRNAs as a therapeutic approach against dengue virus serotypes and concludes that siRNAs against virus and host genes can be next generation treatment of dengue virus infection.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:2221-1691
DOI:10.1016/S2221-1691(13)60057-X