Ubc13 and COOH terminus of Hsp70-interacting protein (CHIP) are required for growth hormone receptor endocytosis

Growth hormone receptor (GHR) endocytosis is a highly regulated process that depends on the binding and activity of the multimeric ubiquitin ligase, SCF(βTrCP) (Skp Cullin F-box). Despite a specific interaction between β-transducin repeat-containing protein (βTrCP) and the GHR, and a strict requirem...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 287; no. 19; p. 15533
Main Authors:	Slotman, Johan A, da Silva Almeida, Ana C, Hassink, Gerco C, van de Ven, Robert H A, van Kerkhof, Peter, Kuiken, Hendrik J, Strous, Ger J
Format:	Journal Article
Language:	English
Published:	United States 04.05.2012
Subjects:	beta-Transducin Repeat-Containing Proteins - genetics beta-Transducin Repeat-Containing Proteins - metabolism Blotting, Western Cell Line, Tumor Endocytosis Humans Lysine - metabolism Microscopy, Fluorescence Protein Binding Protein Multimerization Receptors, Somatotropin - chemistry Receptors, Somatotropin - genetics Receptors, Somatotropin - metabolism RNA Interference Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
ISSN:	1083-351X, 1083-351X
Online Access:	Get more information
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