Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients

Signaling pathways control cell fate decisions that ultimately determine the behavior of cancer cells. Therefore, the dynamics of pathway activity may contain prognostically relevant information different from that contained in the static nature of other types of biomarkers. To investigate this hypo...

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Bibliographic Details
Published in:	Science signaling Vol. 8; no. 408; p. ra130
Main Authors:	Fey, Dirk, Halasz, Melinda, Dreidax, Daniel, Kennedy, Sean P, Hastings, Jordan F, Rauch, Nora, Munoz, Amaya Garcia, Pilkington, Ruth, Fischer, Matthias, Westermann, Frank, Kolch, Walter, Kholodenko, Boris N, Croucher, David R
Format:	Journal Article
Language:	English
Published:	United States 22.12.2015
Subjects:	Adolescent Animals Biomarkers, Tumor - metabolism Cell Line, Tumor Child Child, Preschool Disease-Free Survival Female Follow-Up Studies Humans Infant Male MAP Kinase Kinase 4 - metabolism Models, Biological N-Myc Proto-Oncogene Protein Neoplasms, Experimental - metabolism Neuroblastoma - metabolism Neuroblastoma - mortality Nuclear Proteins - metabolism Oncogene Proteins - metabolism Predictive Value of Tests Signal Transduction Survival Rate Zebrafish - metabolism Zebrafish Proteins - metabolism
ISSN:	1937-9145, 1937-9145
Online Access:	Get more information
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