Non-coding RNA in bladder cancer

Bladder cancer is the tenth most common cancer worldwide and has been associated with high mortality and morbidity. Although the treatment of bladder cancer is based on well-defined tumor classifications and gradings, patients still experience different clinical response. The heterogeneity of this d...

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Vydané v:Cancer letters Ročník 485; s. 38 - 44
Hlavní autori: Li, Yi, Li, Gang, Guo, Xiangyang, Yao, Haochen, Wang, Guoqing, Li, Chong
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Ireland Elsevier B.V 10.08.2020
Elsevier Limited
Predmet:
Apoptosis
Bladder cancer
Cancer
Cancer therapies
Cell cycle
Cell division
Diagnosis
Drug resistance
Epigenetics
Gene expression
Genomes
Humans
Medical diagnosis
Metastasis
MicroRNAs
MicroRNAs - physiology
miRNA
Morbidity
Non-coding RNA
Non-coding RNAs
Pathogenesis
Proteins
RNA, Long Noncoding - physiology
RNA, Untranslated - physiology
Transfer RNA
Tumors
Urinary Bladder Neoplasms - etiology
Urinary Bladder Neoplasms - genetics
Non-coding RNAs
Bladder cancer
Diagnosis
ISSN:0304-3835, 1872-7980, 1872-7980
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Popis
Shrnutí:Bladder cancer is the tenth most common cancer worldwide and has been associated with high mortality and morbidity. Although the treatment of bladder cancer is based on well-defined tumor classifications and gradings, patients still experience different clinical response. The heterogeneity of this disease calls for substantial research with more in-depth molecular characterization, with the hope of identifying new diagnostic and treatment options. In recent years, non-coding RNAs (ncRNAs), particularly, microRNAs (miRNAs), long non-coding RNA (lncRNAs), and circular RNAs (circRNAs) were found to be associated with bladder cancer occurrence and development. This review highlights the recent findings concerning ncRNAs and their relevance to the pathogenesis of bladder cancer. This may provide a foundation for developing highly specific diagnostic tools and more robust therapeutic strategies in the future.
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ISSN:0304-3835
1872-7980
1872-7980
DOI:10.1016/j.canlet.2020.04.023