Roles of Ceramides in Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epid...

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Veröffentlicht in:Journal of clinical medicine Jg. 10; H. 4; S. 792
Hauptverfasser: Hajduch, Eric, Lachkar, Floriane, Ferré, Pascal, Foufelle, Fabienne
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 16.02.2021
MDPI
Schlagworte:
Adipocytes
Biosynthesis
Body fat
Cell growth
Clinical medicine
Diabetes
Enzymes
Fatty acids
Fatty liver
Food and Nutrition
Glucose
Inflammation
Insulin resistance
Life Sciences
Lipids
Liver cirrhosis
Liver diseases
Mammals
Obesity
Oxidation
Review
Roles
Signal transduction
NAFLD
ceramide
NASH
liver
sphingolipids
steatosis
ISSN:2077-0383, 2077-0383
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Abstract Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.
AbstractList Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.
Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.
Author Ferré, Pascal
Hajduch, Eric
Lachkar, Floriane
Foufelle, Fabienne
AuthorAffiliation 2 Institute of Cardiometabolism and Nutrition (ICAN), Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France
1 Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France; eric.hajduch@crc.jussieu.fr (E.H.); floriane.lachkar@sorbonne-universite.fr (F.L.); pascal.ferre@crc.jussieu.fr (P.F.)
AuthorAffiliation_xml – name: 2 Institute of Cardiometabolism and Nutrition (ICAN), Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France
– name: 1 Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France; eric.hajduch@crc.jussieu.fr (E.H.); floriane.lachkar@sorbonne-universite.fr (F.L.); pascal.ferre@crc.jussieu.fr (P.F.)
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  surname: Foufelle
  fullname: Foufelle, Fabienne
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Issue 4
Keywords NAFLD
ceramide
NASH
liver
sphingolipids
steatosis
Language English
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Snippet Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis....
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SubjectTerms Adipocytes
Biosynthesis
Body fat
Cell growth
Clinical medicine
Diabetes
Enzymes
Fatty acids
Fatty liver
Food and Nutrition
Glucose
Inflammation
Insulin resistance
Life Sciences
Lipids
Liver cirrhosis
Liver diseases
Mammals
Obesity
Oxidation
Review
Roles
Signal transduction
Title Roles of Ceramides in Non-Alcoholic Fatty Liver Disease
URI https://www.ncbi.nlm.nih.gov/pubmed/33669443
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https://pubmed.ncbi.nlm.nih.gov/PMC7920467
Volume 10
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