Inhibition of 5-lipoxygenase selectively triggers disruption of c-Myc signaling in prostate cancer cells

Myc is up-regulated in almost all cancer types and is the subject of intense investigation because of its pleiotropic effects controlling a broad spectrum of cell functions. However, despite its recognition as a stand-alone molecular target, development of suitable strategies to block its function i...

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Veröffentlicht in:	The Journal of biological chemistry Jg. 290; H. 8; S. 4994
Hauptverfasser:	Sarveswaran, Sivalokanathan, Chakraborty, Debrup, Chitale, Dhananjay, Sears, Rosalie, Ghosh, Jagadananda
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.02.2015
Schlagworte:	5-Lipoxygenase-Activating Protein Inhibitors - pharmacology Apoptosis - drug effects Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Cell Line, Tumor Down-Regulation - drug effects Down-Regulation - genetics Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Humans Indoles - pharmacology Lipoxygenase Inhibitors - pharmacology Male Prostatic Neoplasms - drug therapy Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - genetics Quinolines - pharmacology Signal Transduction - drug effects Transcription, Genetic - drug effects Transcription, Genetic - genetics MK591 Eicosanoid 5-Lipoxygenase Prostate Cancer Lipoxygenase Pathway Apoptosis Myc (c-Myc)
ISSN:	1083-351X, 1083-351X
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