Denser brain capillary network with preserved pericytes in Alzheimer's disease

Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has been suggested that pericytes are lost in Alzheimer�...

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Bibliographic Details
Published in:	Brain pathology (Zurich, Switzerland) Vol. 30; no. 6; pp. 1071 - 1086
Main Authors:	Fernandez‐Klett, Francisco, Brandt, Lasse, Fernández‐Zapata, Camila, Abuelnor, Basim, Middeldorp, Jinte, Sluijs, Jacqueline A., Curtis, Maurice, Faull, Richard, Harris, Laura W., Bahn, Sabine, Hol, Elly M., Priller, Josef
Format:	Journal Article
Language:	English
Published:	Switzerland John Wiley & Sons, Inc 01.11.2020 John Wiley and Sons Inc
Subjects:	Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Alzheimer's disease (AD) Amyloid Amyloid beta-Peptides - metabolism angiogenesis Blood flow Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology blood–brain barrier (BBB) Brain Capillaries Capillaries - metabolism Capillaries - pathology Central nervous system Cerebral blood flow Cerebrovascular Circulation - physiology clarity Cortex (frontal) Female Frontal Lobe - metabolism Frontal Lobe - pathology Homeostasis Humans Male Middle Aged Morphometry Neurodegenerative diseases Neuroimaging Pathology Peptide Fragments - metabolism Pericytes Pericytes - metabolism Pericytes - pathology Photons stereology two‐photon microscopy blood-brain barrier (BBB) clarity angiogenesis capillaries pericytes stereology Alzheimer's disease (AD) two-photon microscopy
ISSN:	1015-6305, 1750-3639, 1750-3639
Online Access:	Get full text
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