Breaking the fibrinolytic speed limit with microwheel co‐delivery of tissue plasminogen activator and plasminogen

Background To reestablish blood flow in vessels occluded by clots, tissue plasminogen activator (tPA) can be used; however, its efficacy is limited by transport to and into a clot and by the depletion of its substrate, plasminogen. Objectives To overcome these rate limitations, a platform was design...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 20; no. 2; pp. 486 - 497
Main Authors:	Disharoon, Dante, Trewyn, Brian G., Herson, Paco S., Marr, David W. M., Neeves, Keith B.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01.02.2022
Subjects:	Bats Blood flow colloids Drug Delivery Systems Fibrin Fibrin Clot Lysis Time Fibrinolysis Humans Lysis Magnetic fields Magnetic Iron Oxide Nanoparticles Microfluidics Nanoparticles Plasma plasminogen Plasminogen - administration & dosage Speed limits Streptavidin t-Plasminogen activator Thrombolytic drugs Thrombosis - drug therapy tissue plasminogen activator Tissue Plasminogen Activator - administration & dosage fibrinolysis plasminogen tissue plasminogen activator colloids fibrin
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
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