One‐year cognitive follow‐up of COVID‐19 hospitalized patients

Background and purpose Cognitive dysfunction has been observed following recovery from COVID‐19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and event...

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Vydáno v:European journal of neurology Ročník 29; číslo 7; s. 2006 - 2014
Hlavní autoři: Ferrucci, Roberta, Dini, Michelangelo, Rosci, Chiara, Capozza, Antonella, Groppo, Elisabetta, Reitano, Maria R., Allocco, Elisa, Poletti, Barbara, Brugnera, Agostino, Bai, Francesca, Monti, Alessia, Ticozzi, Nicola, Silani, Vincenzo, Centanni, Stefano, D’Arminio Monforte, Antonella, Tagliabue, Luca, Priori, Alberto
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.07.2022
John Wiley and Sons Inc
Témata:
Cognition
Cognition Disorders - psychology
Cognitive ability
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - etiology
COVID-19
Follow-Up Studies
Humans
Impairment
Infectious Diseases
Information processing
Long COVID
Memory
neuropsychological evaluation
Neuropsychological Tests
Olfaction disorders
Original
Patients
Spatial memory
Taste disorders
COVID-19
neuropsychological evaluation
cognition
long-COVID
ISSN:1351-5101, 1468-1331, 1468-1331
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Shrnutí:Background and purpose Cognitive dysfunction has been observed following recovery from COVID‐19. To the best of our knowledge, however, no study has assessed the progression of cognitive impairment after 1 year. The aim was to assess cognitive functioning at 1 year from hospital discharge, and eventual associations with specific clinical variables. Methods Seventy‐six patients (aged 22–74 years) who had been hospitalized for COVID‐19 were recruited. Patients received neuropsychological assessments at 5 (n = 76) and 12 months (n = 53) from hospital discharge. Results Over half (63.2%) of the patients had deficits in at least one test at 5 months. Compared to the assessment at 5 months, verbal memory, attention and processing speed improved significantly after 1 year (all p < 0.05), whereas visuospatial memory did not (all p > 0.500). The most affected domains after 1 year were processing speed (28.3%) and long‐term visuospatial (18.1%) and verbal (15.1%) memory. Lower PaO2/FiO2 ratios in the acute phase were associated with worse verbal long‐term memory (p = 0.029) and visuospatial learning (p = 0.041) at 5 months. Worse visuospatial long‐term memory at 5 months was associated with hyposmia (p = 0.020) and dysgeusia (p = 0.037). Conclusion Our study expands the results from previous studies showing that cognitive impairment can still be observed after 1 year. Patients with severe COVID‐19 should receive periodic cognitive follow‐up evaluations, as cognitive deficits in recovered patients could have social and occupational implications. Cognitive impairment can still be observed in almost 50% of formerly hospitalized patients with COVID‐19 at 1 year from respiratory clinical recovery. Clinicians should be aware that the ratio of arterial oxygen partial pressure to fractional inspired oxygen and hyposmia/dysgeusia might represent risk factors for the development of cognitive impairment in COVID‐19.
Bibliografie:ObjectType-Article-1
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ISSN:1351-5101
1468-1331
1468-1331
DOI:10.1111/ene.15324