Desensitizing highly sensitized heart transplant candidates with the combination of belatacept and proteasome inhibition

HLA antibodies pose a significant barrier to transplantation and current strategies to reduce allosensitization are limited. We hypothesized that augmenting proteasome inhibitor (PI) based desensitization with costimulation blockade (belatacept) to mitigate germinal center (GC) responses might incre...

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Bibliographic Details
Published in:	American journal of transplantation Vol. 20; no. 12; pp. 3620 - 3630
Main Authors:	Alishetti, Shudhanshu, Farr, Maryjane, Jennings, Douglas, Serban, Geo, Uriel, Nir, Sayer, Gabriel, Vasilescu, Rodica, Restaino, Susan, Chong, Anita S., Habal, Marlena V.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Limited 01.12.2020
Subjects:	Abatacept - therapeutic use Antibodies CD38 antigen Complement component C1q costimulation Cytotoxicity desensitization Desensitization (Psychology) Graft Rejection - drug therapy Graft Rejection - prevention & control Heart Transplantation heart transplantation/cardiology Heart transplants Helper cells histocompatibility Histocompatibility antigen HLA Histocompatibility Testing HLA Antigens Immunological memory immunosuppressant—fusion proteins and monoclonal antibodies: belatacept immunosuppression/immune modulation Isoantibodies Leukocytes, Mononuclear Lymphocytes B Memory cells Monoclonal antibodies natural killer (NK) cells/NK receptors Natural killer cells PD-1 protein Peripheral blood mononuclear cells Phenotypes Proteasome Endopeptidase Complex Proteasome inhibitors sensitization translational research/science translational research/science costimulation immunosuppressant-fusion proteins and monoclonal antibodies: belatacept immunosuppression/immune modulation histocompatibility natural killer (NK) cells/NK receptors heart transplantation/cardiology sensitization desensitization
ISSN:	1600-6135, 1600-6143, 1600-6143
Online Access:	Get full text
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