In vivo human head MRI at 10.5T: A radiofrequency safety study and preliminary imaging results

Purpose The purpose of this study is to safely acquire the first human head images at 10.5T. Methods To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SA...

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Vydané v:Magnetic resonance in medicine Ročník 84; číslo 1; s. 484 - 496
Hlavní autori: Sadeghi‐Tarakameh, Alireza, DelaBarre, Lance, Lagore, Russell L., Torrado‐Carvajal, Angel, Wu, Xiaoping, Grant, Andrea, Adriany, Gregor, Metzger, Gregory J., Van de Moortele, Pierre‐Francois, Ugurbil, Kamil, Atalar, Ergin, Eryaman, Yigitcan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley Subscription Services, Inc 01.07.2020
Predmet:
10.5T
Computer Simulation
head imaging
Human subjects
Humans
Image acquisition
Image transmission
In vivo methods and tests
Magnetic Resonance Imaging
Mathematical models
MRI
Phantoms, Imaging
Quadratures
Radio frequency
Radio Waves
radiofrequency safety
Safety
ultra‐high field
Workflow
head imaging
MRI
ultra-high field
radiofrequency safety
10.5T
ISSN:0740-3194, 1522-2594, 1522-2594
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Shrnutí:Purpose The purpose of this study is to safely acquire the first human head images at 10.5T. Methods To ensure safety of subjects, we validated the electromagnetic simulation model of our coil. We obtained quantitative agreement between simulated and experimental B1+ and specific absorption rate (SAR). Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects. We conducted all experiments and imaging sessions in a controlled radiofrequency safety lab and the whole‐body 10.5T scanner in the Center for Magnetic Resonance Research. Results Quantitative agreement between the simulated and experimental results was obtained including S‐parameters, B1+ maps, and SAR. We calculated peak 10 g average SAR using 4 different realistic human body models for a quadrature excitation and demonstrated that the peak 10 g SAR variation between subjects was less than 30%. We calculated safe power limits based on this set and used those limits to acquire T2‐ and T2∗‐weighted images of human subjects at 10.5T. Conclusions In this study, we acquired the first in vivo human head images at 10.5T using an 8‐channel transmit/receive coil. We implemented and expanded a previously proposed workflow to validate the electromagnetic simulation model of the 8‐channel transmit/receive coil. Using the validated coil model, we calculated radiofrequency power levels to safely image human subjects.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.28093