Adipose tissue‐derived extracellular matrix hydrogels as a release platform for secreted paracrine factors

Fat grafting is an established clinical intervention to promote tissue repair. The role of the fat's extracellular matrix (ECM) in regeneration is largely neglected. We investigated in vitro the use of human adipose tissue‐derived ECM hydrogels as release platform for factors secreted by adipos...

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Bibliographic Details
Published in:	Journal of tissue engineering and regenerative medicine Vol. 13; no. 6; pp. 973 - 985
Main Authors:	Dongen, Joris A., Getova, Vasilena, Brouwer, Linda A., Liguori, Gabriel R., Sharma, Prashant K., Stevens, Hieronymus P., Lei, Berend, Harmsen, Martin C.
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.06.2019 John Wiley and Sons Inc
Subjects:	acellular matrix Adipose tissue Adipose Tissue - metabolism Angiogenesis Animals Cattle Cell Proliferation - drug effects Culture Media, Conditioned - pharmacology decellularization Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes Mellitus - pathology DNA Elasticity Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Glycosaminoglycans - metabolism growth factors Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Humans hydrogel Hydrogels Hydrogels - chemistry Mesenchymal stem cells Neovascularization, Physiologic - drug effects Paracrine Communication - drug effects Paracrine signalling Reconstructive surgery Regeneration Regenerative medicine Stability Stromal cells Stromal Cells - drug effects Stromal Cells - metabolism Sulfates - metabolism Tissue engineering Viscoelasticity Viscosity Wound healing wound healing decellularization acellular matrix growth factors hydrogel mesenchymal stem cells
ISSN:	1932-6254, 1932-7005, 1932-7005
Online Access:	Get full text
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