Cytosolic detection of phagosomal bacteria—Mechanisms underlying PAMP exodus from the phagosome into the cytosol

The metazoan innate immune system senses bacterial infections by detecting highly conserved bacterial molecules, termed pathogen‐associated molecular patterns (PAMPs). PAMPs are detected by a variety of host pattern recognition receptors (PRRs), whose function is to coordinate downstream immune resp...

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Bibliographic Details
Published in:	Molecular microbiology Vol. 116; no. 6; pp. 1420 - 1432
Main Authors:	Ragland, Stephanie A., Kagan, Jonathan C.
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01.12.2021
Subjects:	Animals Bacteria Bacteria - genetics Bacteria - metabolism Bacterial diseases Bacterial infections Bacterial Infections - genetics Bacterial Infections - metabolism Bacterial Infections - microbiology Bacterial Infections - physiopathology caspase‐11 caspase‐4 caspase‐5 cGAS cyclic dinucleotides Cytosol Cytosol - metabolism Cytosol - microbiology guanylate binding proteins Humans Immune response Immune system Innate immunity lipopolysaccharide macrophage Membranes Pathogen-Associated Molecular Pattern Molecules - metabolism pathogen‐associated molecular pattern Pattern recognition pattern recognition receptor Pattern recognition receptors Phagocytes Phagocytosis phagosome Phagosomes Phagosomes - genetics Phagosomes - metabolism Phagosomes - microbiology Receptor mechanisms Receptors, Pattern Recognition - genetics Receptors, Pattern Recognition - metabolism STING caspase-5 cyclic dinucleotides cGAS STING macrophage phagosome caspase-11 lipopolysaccharide guanylate binding proteins pathogen-associated molecular pattern caspase-4 pattern recognition receptor
ISSN:	0950-382X, 1365-2958, 1365-2958
Online Access:	Get full text
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