Reduction in gray matter of cerebellum in schizophrenia and its influence on static and dynamic connectivity

Pathophysiological and atrophic changes in the cerebellum have been well‐documented in schizophrenia. Reduction of gray matter (GM) in the cerebellum was confirmed across cognitive and motor cerebellar modules in schizophrenia. Such abnormalities in the cerebellum could potentially have widespread e...

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Published in:Human brain mapping Vol. 40; no. 2; pp. 517 - 528
Main Authors: He, Hui, Luo, Cheng, Luo, Yuling, Duan, Mingjun, Yi, Qizhong, Biswal, Bharat B., Yao, Dezhong
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.02.2019
Subjects:
Abnormalities
Adult
Cerebellum
Cerebellum - diagnostic imaging
Cerebellum - pathology
Cerebellum - physiopathology
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - pathology
Cerebral Cortex - physiopathology
Cognitive ability
Connectome
Cortex
cortical–subcortical networks
Female
functional connectivity
Gray Matter - diagnostic imaging
Gray Matter - pathology
Gray Matter - physiopathology
Humans
Magnetic Resonance Imaging
Male
Mental disorders
Middle Aged
Modules
Motors
Nerve Net - diagnostic imaging
Nerve Net - pathology
Nerve Net - physiopathology
Neuroimaging - methods
Patients
Reduction
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - pathology
Schizophrenia - physiopathology
Sensorimotor system
Structure-function relationships
Substantia grisea
temporal variability
Thalamus
Thalamus - diagnostic imaging
Thalamus - pathology
Thalamus - physiopathology
voxel‐base morphometry
temporal variability
functional connectivity
cortical-subcortical networks
cerebellum
voxel-base morphometry
ISSN:1065-9471, 1097-0193, 1097-0193
Online Access:Get full text
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Summary:Pathophysiological and atrophic changes in the cerebellum have been well‐documented in schizophrenia. Reduction of gray matter (GM) in the cerebellum was confirmed across cognitive and motor cerebellar modules in schizophrenia. Such abnormalities in the cerebellum could potentially have widespread effects on both sensorimotor and cognitive symptoms. In this study, we investigated how reduction change in the cerebellum affects the static and the dynamic functional connectivity (FC) between the cerebellum and cortical/subcortical networks in schizophrenia. Reduction of GM in the cerebellum was confirmed across the cognitive and motor cerebellar modules in schizophrenic subjects. Results from this study demonstrates that the extent of reduction of GM within cerebellum correlated with increased static FCs between the cerebellum and the cortical/subcortical networks, including frontoparietal network (FPN), and thalamus in patients with schizophrenia. Decreased GM in the cerebellum was also associated with a declined dynamic FC between the cerebellum and the FPN in schizophrenic subjects. The severity of patients' positive symptom was related to these structural‐functional coupling score of cerebellum. These findings identified potential cerebellar driven functional changes associated with positive symptom deficits. A post hoc analysis exploring the effect of changed FC within cerebellum, confirmed that a significant positive relationship, between dynamic FCs of cerebellum–thalamus and intracerebellum existed in patients, but not in controls. The reduction of GM within the cerebellum might be associated with modulation of cerebellum–thalamus, and contributes to the dysfunctional cerebellar‐cortical communication in schizophrenia. Our results provide a new insight into the role of cerebellum in understanding the pathophysiological of schizophrenia.
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Funding information National Nature Science Foundation of China, Grant/Award Numbers: 81771822, 81861128001, 81660233, 81571759, 81471638; Sichuan Province Science and Technology Support Project, Grant/Award Numbers: No.2017HH0001No.2017SZ0004, 2017HH0001, 2017SZ0004; Project of Scientific Expenses of the Ministry of Education, Grant/Award Number: 2017PT14; “111” project of China, Grant/Award Number: B12027
ISSN:1065-9471
1097-0193
1097-0193
DOI:10.1002/hbm.24391