Dynamics of Top‐Down Control and Motor Networks in Parkinson's Disease
Background Motor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics between sensorimotor network and top‐down control networks (frontal–parietal, cingulo‐opercular, and cerebellar) in PD and at determining t...
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| Published in: | Movement disorders Vol. 36; no. 4; pp. 916 - 926 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.04.2021
Wiley Subscription Services, Inc |
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| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
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| Abstract | Background
Motor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics between sensorimotor network and top‐down control networks (frontal–parietal, cingulo‐opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks.
Methods
We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top‐down control networks in 36 PD patients (OFF medication, PD‐OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication.
Results
The dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal–parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo‐opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD‐OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake.
Conclusions
Dopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society |
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| AbstractList | Motor symptoms in Parkinson's disease (PD) patients might be related to high-level task-control deficits. We aimed at investigating the dynamics between sensorimotor network and top-down control networks (frontal-parietal, cingulo-opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks.
We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top-down control networks in 36 PD patients (OFF medication, PD-OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication.
The dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal-parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo-opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD-OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake.
Dopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society. Motor symptoms in Parkinson's disease (PD) patients might be related to high-level task-control deficits. We aimed at investigating the dynamics between sensorimotor network and top-down control networks (frontal-parietal, cingulo-opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks.BACKGROUNDMotor symptoms in Parkinson's disease (PD) patients might be related to high-level task-control deficits. We aimed at investigating the dynamics between sensorimotor network and top-down control networks (frontal-parietal, cingulo-opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks.We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top-down control networks in 36 PD patients (OFF medication, PD-OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication.METHODSWe investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top-down control networks in 36 PD patients (OFF medication, PD-OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication.The dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal-parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo-opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD-OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake.RESULTSThe dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal-parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo-opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD-OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake.Dopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society.CONCLUSIONSDopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society. BackgroundMotor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics between sensorimotor network and top‐down control networks (frontal–parietal, cingulo‐opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks.MethodsWe investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top‐down control networks in 36 PD patients (OFF medication, PD‐OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication.ResultsThe dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal–parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo‐opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD‐OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake.ConclusionsDopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society Background Motor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics between sensorimotor network and top‐down control networks (frontal–parietal, cingulo‐opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks. Methods We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top‐down control networks in 36 PD patients (OFF medication, PD‐OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication. Results The dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal–parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo‐opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD‐OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake. Conclusions Dopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society |
| Author | Hallett, Mark Chen, Li Bedard, Patrick Horovitz, Silvina G. |
| AuthorAffiliation | 1 Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA 2 Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China |
| AuthorAffiliation_xml | – name: 2 Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China – name: 1 Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA |
| Author_xml | – sequence: 1 givenname: Li orcidid: 0000-0002-2380-1738 surname: Chen fullname: Chen, Li email: chenliidea@sina.com organization: Affiliated Hospital of North Sichuan Medical College – sequence: 2 givenname: Patrick surname: Bedard fullname: Bedard, Patrick organization: National Institutes of Health – sequence: 3 givenname: Mark orcidid: 0000-0002-3180-6811 surname: Hallett fullname: Hallett, Mark organization: National Institutes of Health – sequence: 4 givenname: Silvina G. surname: Horovitz fullname: Horovitz, Silvina G. email: silvina.horovitz@nih.gov organization: National Institutes of Health |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33404161$$D View this record in MEDLINE/PubMed |
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Motor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics... Motor symptoms in Parkinson's disease (PD) patients might be related to high-level task-control deficits. We aimed at investigating the dynamics between... BackgroundMotor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics... |
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| SubjectTerms | Cerebellum Cognitive ability Dopamine dynamic functional connectivity Functional magnetic resonance imaging Humans Levodopa Magnetic Resonance Imaging motor network Motor task performance Movement disorders Neural Pathways - diagnostic imaging Neurodegenerative diseases Parkinson Disease - drug therapy Parkinson's disease Sensorimotor system top‐down control networks |
| Title | Dynamics of Top‐Down Control and Motor Networks in Parkinson's Disease |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.28461 https://www.ncbi.nlm.nih.gov/pubmed/33404161 https://www.proquest.com/docview/2512251960 https://www.proquest.com/docview/2475528567 https://pubmed.ncbi.nlm.nih.gov/PMC8373438 |
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