Dynamics of Top‐Down Control and Motor Networks in Parkinson's Disease

Background Motor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics between sensorimotor network and top‐down control networks (frontal–parietal, cingulo‐opercular, and cerebellar) in PD and at determining t...

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Published in:Movement disorders Vol. 36; no. 4; pp. 916 - 926
Main Authors: Chen, Li, Bedard, Patrick, Hallett, Mark, Horovitz, Silvina G.
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2021
Wiley Subscription Services, Inc
Subjects:
Cerebellum
Cognitive ability
Dopamine
dynamic functional connectivity
Functional magnetic resonance imaging
Humans
Levodopa
Magnetic Resonance Imaging
motor network
Motor task performance
Movement disorders
Neural Pathways - diagnostic imaging
Neurodegenerative diseases
Parkinson Disease - drug therapy
Parkinson's disease
Sensorimotor system
top‐down control networks
dynamic functional connectivity
top-down control networks
motor network
Parkinson's disease
dopamine
ISSN:0885-3185, 1531-8257, 1531-8257
Online Access:Get full text
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Summary:Background Motor symptoms in Parkinson's disease (PD) patients might be related to high‐level task‐control deficits. We aimed at investigating the dynamics between sensorimotor network and top‐down control networks (frontal–parietal, cingulo‐opercular, and cerebellar) in PD and at determining the effects of levodopa on the dynamics of these networks. Methods We investigated dynamic functional connectivity (dFC), during resting state functional magnetic resonance imaging, between sensorimotor network and top‐down control networks in 36 PD patients (OFF medication, PD‐OFF) and 36 healthy volunteers. We further assessed the effect of medication on dFC in18 PD patients who were also scanned ON medication. Results The dFC analyses identified three discrete states: State I (35.68%) characterized by connections between the cerebellum and sensorimotor network, State II (34.17%) with connections between the sensorimotor and frontal–parietal network, and State III (30.15%) with connection between the sensorimotor and cingulo‐opercular network. PD patients have significantly fewer occurrences and overall spent less time (shorter dwell time) in State II compared to healthy controls. After levodopa intake, dwell time improved toward normal. The change in dwell time before and after taking levodopa was negatively related to the respective changes in Unified Parkinson's Disease Rating Scale, Part III. PD‐OFF showed significantly decreased connectivity between sensorimotor and control networks and increased connectivity within control networks. These changes were partially improved after levodopa intake. Conclusions Dopamine depletion in PD is associated with abnormalities in temporal and spatial properties between cognitive control and sensorimotor network, possibly contributing to clinical deficits. Levodopa partially restores the network function toward the values observed in healthy volunteers. © 2021 International Parkinson and Movement Disorder Society
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ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.28461