Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling

Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers cardioprotection via pleiotropic effects including antio...

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Vydané v:	Frontiers in endocrinology (Lausanne) Ročník 13; s. 941822
Hlavní autori:	Papatheodorou, Ioanna, Makrecka-Kuka, Marina, Kuka, Janis, Liepinsh, Edgars, Dambrova, Maija, Lazou, Antigone
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Frontiers Media S.A 15.08.2022
Predmet:	cardioprotection electron transport system Endocrinology fatty acid oxidation ischemia/reperfusion mitochondrial respiration ROS
ISSN:	1664-2392, 1664-2392
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