Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling

Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers cardioprotection via pleiotropic effects including antio...

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Bibliographic Details
Published in:	Frontiers in endocrinology (Lausanne) Vol. 13; p. 941822
Main Authors:	Papatheodorou, Ioanna, Makrecka-Kuka, Marina, Kuka, Janis, Liepinsh, Edgars, Dambrova, Maija, Lazou, Antigone
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 15.08.2022
Subjects:	cardioprotection electron transport system Endocrinology fatty acid oxidation ischemia/reperfusion mitochondrial respiration ROS
ISSN:	1664-2392, 1664-2392
Online Access:	Get full text
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