First clinical cases of OXA-48-producing carbapenem-resistant Klebsiella pneumoniae in the United States: the "menace" arrives in the new world

OXA-48 has emerged as a major carbapenemase associated with the Enterobacteriaceae in Europe, North Africa, and Asia. We report the first two clinical cases of OXA-48-type carbapenemase-producing Enterobacteriaceae in the United States from patients recently hospitalized in Saudi Arabia and India. E...

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Veröffentlicht in:Journal of clinical microbiology Jg. 51; H. 2; S. 680
Hauptverfasser: Mathers, Amy J, Hazen, Kevin C, Carroll, Joanne, Yeh, Anthony J, Cox, Heather L, Bonomo, Robert A, Sifri, Costi D
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.02.2013
Schlagworte:
Anti-Bacterial Agents - pharmacology
beta-Lactam Resistance - genetics
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
Female
Humans
Klebsiella Infections - diagnosis
Klebsiella Infections - microbiology
Klebsiella pneumoniae - classification
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - genetics
Microbial Sensitivity Tests
Middle Aged
Multilocus Sequence Typing
United States
United States
ISSN:1098-660X, 1098-660X
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Zusammenfassung:OXA-48 has emerged as a major carbapenemase associated with the Enterobacteriaceae in Europe, North Africa, and Asia. We report the first two clinical cases of OXA-48-type carbapenemase-producing Enterobacteriaceae in the United States from patients recently hospitalized in Saudi Arabia and India. Each is more carbapenem resistant than nearly all previously reported OXA-48-type-producing Enterobacteriaceae.
Bibliographie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:1098-660X
1098-660X
DOI:10.1128/JCM.02580-12