Linezolid resistance in multidrug-resistant mycobacterium tuberculosis: A systematic review and meta-analysis
Introduction: Linezolid (LNZ) is an effective antibiotic to treat patients with multidrug-resistant tuberculosis (MDR-TB) treatment failure. M. tuberculosis strains resistant to isoniazid and rifampin are defined as MDR-TB. In recent years, resistance to LNZ among MDR-TB cases has been reported in s...
Uloženo v:
| Vydáno v: | Frontiers in pharmacology Ročník 13; s. 955050 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Frontiers Media S.A
30.08.2022
|
| Témata: | |
| ISSN: | 1663-9812, 1663-9812 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Shrnutí: | Introduction:
Linezolid (LNZ) is an effective antibiotic to treat patients with multidrug-resistant tuberculosis (MDR-TB) treatment failure.
M. tuberculosis
strains resistant to isoniazid and rifampin are defined as MDR-TB. In recent years, resistance to LNZ among MDR-TB cases has been reported in several different countries. In this study, we performed a systematic review and meta-analysis to investigate the prevalence of LNZ resistance among MDR-TB isolates.
Methods:
The databases of Embase, PubMed/Medline, and Web of Science were searched systematically from January 2000 to April 2021. Statistical analyses were performed by using Comprehensive Meta-Analysis software. Heterogeneity was reported by using the t-squared statistic and Q-statistic. Begg’s rank correlation in combination with the funnel plot were used to evaluate any possible publication bias.
Results:
In total, 25 studies were selected for meta-analysis from 14 different countries; the majority was from China (n = 5) and Turkey (n = 4). Moreover, 7,366 patients were infected with MDR
M. tuberculosis
. Among the study population, 98 patients were co-infected with HIV, and 18 patients with hepatitis C virus (HCV). Furthermore, 28 cases had diabetes, and139 cases were alcohol abuser. Overall, 4,956 MDR
M. tuberculosis
strains were isolated from TB patients. The pooled frequency of LNZ resistance among the clinical isolates of MDR
M. tuberculosis
was 4.2% (95%). Begg’s (
p
= 0.72) test showed no evidence of publication bias.
Conclusion:
LNZ resistance among MDR M. tuberculosis isolates is increasing. On the other hand, long-term treatment of MDR-TB cases with LNZ alone is associated with several adverse effects. Thus, it is recommended that newer anti-TB drugs, including bedaquiline and delamanid, in combination with linezolid could increase its effectiveness and decrease toxicities. However, more studies should be done in this field. |
|---|---|
| Bibliografie: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 Reviewed by: Alaa Abouelfetouh, Alexandria university, Egypt This article was submitted to Pharmacology of Infectious Diseases, a section of the journal Frontiers in Pharmacology Edited by: Ahmed F. El-Yazbi, Alexandria University, Egypt Hasan Ejaz, Al Jouf University, Saudi Arabia These authors have contributed equally to this work and share first authorship |
| ISSN: | 1663-9812 1663-9812 |
| DOI: | 10.3389/fphar.2022.955050 |