Fabrication of chondroitin sulfate calcium complex and its chondrocyte proliferation in vitro
[Display omitted] •Chondroitin sulfate calcium complex (CSCa) was fabricated by cation exchange method.•Characterization of CSCa was analyzed by EDS, AFM, FTIR, NMR, XRD, TGA and DSC.•Chondrocyte proliferation bioactivity of CSCa was investigated in vitro.•CSCa increased intracellular calcium ions a...
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| Published in: | Carbohydrate polymers Vol. 254; p. 117282 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
Elsevier Ltd
15.02.2021
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| Subjects: | |
| ISSN: | 0144-8617, 1879-1344, 1879-1344 |
| Online Access: | Get full text |
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| Abstract | [Display omitted]
•Chondroitin sulfate calcium complex (CSCa) was fabricated by cation exchange method.•Characterization of CSCa was analyzed by EDS, AFM, FTIR, NMR, XRD, TGA and DSC.•Chondrocyte proliferation bioactivity of CSCa was investigated in vitro.•CSCa increased intracellular calcium ions and activated the TGF-β/Smads pathway.
Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated in vitro. Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %. Characterization of CSCa was performed by EDS, AFM, FTIR, UV, XRD and 1H-NMR. It was found that calcium ions were integrated with CS by binding the sulfate or carboxyl groups. The thermal properties analysis indicated CSCa had a good thermal stability by TGA and DSC. CSCa could interact the calcium-sensing receptor increasing the intracellular calcium ions and influence the cell cycle. The TGF-β1 secretion induced by CSCa could activate the TGF-β/Smads pathway and change the genes associated proliferation expression ultimately leading to the chondrocyte proliferation. This research probably has an important implication for understanding the effect of CSCa on bone care as food supplements. |
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| AbstractList | Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated in vitro. Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %. Characterization of CSCa was performed by EDS, AFM, FTIR, UV, XRD and 1H-NMR. It was found that calcium ions were integrated with CS by binding the sulfate or carboxyl groups. The thermal properties analysis indicated CSCa had a good thermal stability by TGA and DSC. CSCa could interact the calcium-sensing receptor increasing the intracellular calcium ions and influence the cell cycle. The TGF-β1 secretion induced by CSCa could activate the TGF-β/Smads pathway and change the genes associated proliferation expression ultimately leading to the chondrocyte proliferation. This research probably has an important implication for understanding the effect of CSCa on bone care as food supplements.Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated in vitro. Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %. Characterization of CSCa was performed by EDS, AFM, FTIR, UV, XRD and 1H-NMR. It was found that calcium ions were integrated with CS by binding the sulfate or carboxyl groups. The thermal properties analysis indicated CSCa had a good thermal stability by TGA and DSC. CSCa could interact the calcium-sensing receptor increasing the intracellular calcium ions and influence the cell cycle. The TGF-β1 secretion induced by CSCa could activate the TGF-β/Smads pathway and change the genes associated proliferation expression ultimately leading to the chondrocyte proliferation. This research probably has an important implication for understanding the effect of CSCa on bone care as food supplements. Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated in vitro. Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %. Characterization of CSCa was performed by EDS, AFM, FTIR, UV, XRD and 1H-NMR. It was found that calcium ions were integrated with CS by binding the sulfate or carboxyl groups. The thermal properties analysis indicated CSCa had a good thermal stability by TGA and DSC. CSCa could interact the calcium-sensing receptor increasing the intracellular calcium ions and influence the cell cycle. The TGF-β1 secretion induced by CSCa could activate the TGF-β/Smads pathway and change the genes associated proliferation expression ultimately leading to the chondrocyte proliferation. This research probably has an important implication for understanding the effect of CSCa on bone care as food supplements. [Display omitted] •Chondroitin sulfate calcium complex (CSCa) was fabricated by cation exchange method.•Characterization of CSCa was analyzed by EDS, AFM, FTIR, NMR, XRD, TGA and DSC.•Chondrocyte proliferation bioactivity of CSCa was investigated in vitro.•CSCa increased intracellular calcium ions and activated the TGF-β/Smads pathway. Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte were investigated in vitro. Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %. Characterization of CSCa was performed by EDS, AFM, FTIR, UV, XRD and 1H-NMR. It was found that calcium ions were integrated with CS by binding the sulfate or carboxyl groups. The thermal properties analysis indicated CSCa had a good thermal stability by TGA and DSC. CSCa could interact the calcium-sensing receptor increasing the intracellular calcium ions and influence the cell cycle. The TGF-β1 secretion induced by CSCa could activate the TGF-β/Smads pathway and change the genes associated proliferation expression ultimately leading to the chondrocyte proliferation. This research probably has an important implication for understanding the effect of CSCa on bone care as food supplements. |
| ArticleNumber | 117282 |
| Author | Mo, Haizhen Zhang, Hongru Richel, Aurore Zhang, Chunhui Zhang, Zhiqiang Shen, Qingshan Li, Juan Qin, Xiaojie |
| Author_xml | – sequence: 1 givenname: Qingshan surname: Shen fullname: Shen, Qingshan organization: Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, China – sequence: 2 givenname: Chunhui surname: Zhang fullname: Zhang, Chunhui email: dr_zch@163.com organization: Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, China – sequence: 3 givenname: Haizhen surname: Mo fullname: Mo, Haizhen organization: School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China – sequence: 4 givenname: Hongru surname: Zhang fullname: Zhang, Hongru organization: Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, China – sequence: 5 givenname: Xiaojie surname: Qin fullname: Qin, Xiaojie organization: Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, China – sequence: 6 givenname: Juan surname: Li fullname: Li, Juan organization: Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, China – sequence: 7 givenname: Zhiqiang surname: Zhang fullname: Zhang, Zhiqiang organization: Shandong Haiyu Biotechnology Co., Ltd., Jining, 272113, China – sequence: 8 givenname: Aurore surname: Richel fullname: Richel, Aurore organization: University of Liege-Gembloux Agro-Bio Tech, Laboratory of Biomass and Green Technologies, Passage des déportés 2, B-5030 Gembloux, Belgium |
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| Keywords | Bone care Chondroitin sulfate Proliferation Calcium Chondrocyte |
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•Chondroitin sulfate calcium complex (CSCa) was fabricated by cation exchange method.•Characterization of CSCa was analyzed by EDS, AFM,... Chondroitin sulfate (CS)-calcium complex (CSCa) was fabricated, and the structural characteristics of CSCa and its proliferative bioactivity to the chondrocyte... |
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| SubjectTerms | Apoptosis Apoptosis - drug effects bioactive properties Bone care Calcium Calcium - chemistry Calcium - metabolism Calcium - pharmacology calcium receptors Calcium sensing receptors Carboxyl groups CASR protein, human Cell Cycle Cell Cycle - drug effects Cell Proliferation Cell Proliferation - drug effects Cells, Cultured Chemistry Chimie Chondrocyte Chondrocyte proliferation Chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Chondroitin sulfate Chondroitin Sulfates Chondroitin Sulfates - chemical synthesis Chondroitin Sulfates - chemistry Chondroitin Sulfates - pharmacology Food supplements Gene Expression Holding capacity Humans In Vitro Techniques Intracellular calcium Magnetic Resonance Spectroscopy Materials Chemistry Models, Biological Molecular Docking Simulation Molecular Structure nuclear magnetic resonance spectroscopy Organic Chemistry Particle Size Physical, chemical, mathematical & earth Sciences Physique, chimie, mathématiques & sciences de la terre Polymers and Plastics Proliferation Receptors, Calcium-Sensing Receptors, Calcium-Sensing - chemistry Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism secretion Spectroscopy, Fourier Transform Infrared Structural characteristics sulfates TGFB1 protein, human thermal stability Transforming Growth Factor beta1 Transforming Growth Factor beta1 - metabolism |
| Title | Fabrication of chondroitin sulfate calcium complex and its chondrocyte proliferation in vitro |
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