Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe

Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis , representing 12 distinct genotypes, obtained from human remains from eighteenth-century...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 6; číslo 1; s. 6717
Hlavní autoři:	Kay, Gemma L., Sergeant, Martin J., Zhou, Zhemin, Chan, Jacqueline Z.-M., Millard, Andrew, Quick, Joshua, Szikossy, Ildikó, Pap, Ildikó, Spigelman, Mark, Loman, Nicholas J., Achtman, Mark, Donoghue, Helen D., Pallen, Mark J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 07.04.2015 Nature Publishing Group Nature Pub. Group
Témata:	631/208/212/2142 631/208/212/2304 631/326/41/1470 692/699/255/1856 Adult Bayes Theorem Coinfection - microbiology DNA, Bacterial - analysis Europe - epidemiology Female Genome, Bacterial - genetics Genotype Genotypes History, 18th Century Humanities and Social Sciences Humans Hungary - epidemiology Male Metagenomics Middle Aged Molecular Epidemiology multidisciplinary Mycobacterium tuberculosis - genetics Phylogeny Science Science (multidisciplinary) Tuberculosis Tuberculosis - epidemiology Tuberculosis - history Tuberculosis - microbiology Young Adult Hungary Europe
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis , representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. Tuberculosis was once a major killer in Europe. Here the authors use metagenomics to obtain genomic sequences of Mycobacterium tuberculosis from human remains from eighteenth-century Hungary, revealing mixed infections within individuals as well as presence of the same strain in two individuals.
AbstractList	Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. Tuberculosis was once a major killer in Europe. Here the authors use metagenomics to obtain genomic sequences of Mycobacterium tuberculosis from human remains from eighteenth-century Hungary, revealing mixed infections within individuals as well as presence of the same strain in two individuals. Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis , representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis, representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis , representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ancestor of this lineage in the late Roman period. We find that most bodies yielded more than one M. tuberculosis genotype and we document an intimate epidemiological link between infections in two long-dead individuals. Our results suggest that metagenomic approaches usefully inform detection and characterization of historical and contemporary infections. Tuberculosis was once a major killer in Europe. Here the authors use metagenomics to obtain genomic sequences of Mycobacterium tuberculosis from human remains from eighteenth-century Hungary, revealing mixed infections within individuals as well as presence of the same strain in two individuals.
ArticleNumber	6717
Author	Quick, Joshua Spigelman, Mark Szikossy, Ildikó Pap, Ildikó Achtman, Mark Pallen, Mark J. Loman, Nicholas J. Zhou, Zhemin Sergeant, Martin J. Millard, Andrew Kay, Gemma L. Donoghue, Helen D. Chan, Jacqueline Z.-M.
Author_xml	– sequence: 1 givenname: Gemma L. surname: Kay fullname: Kay, Gemma L. organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road – sequence: 2 givenname: Martin J. surname: Sergeant fullname: Sergeant, Martin J. organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road – sequence: 3 givenname: Zhemin surname: Zhou fullname: Zhou, Zhemin organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road – sequence: 4 givenname: Jacqueline Z.-M. surname: Chan fullname: Chan, Jacqueline Z.-M. organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road – sequence: 5 givenname: Andrew surname: Millard fullname: Millard, Andrew organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road – sequence: 6 givenname: Joshua surname: Quick fullname: Quick, Joshua organization: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham – sequence: 7 givenname: Ildikó surname: Szikossy fullname: Szikossy, Ildikó organization: Department of Anthropology, Hungarian Natural History Museum, Ludovika tér 2–6 – sequence: 8 givenname: Ildikó surname: Pap fullname: Pap, Ildikó organization: Department of Anthropology, Hungarian Natural History Museum, Ludovika tér 2–6 – sequence: 9 givenname: Mark surname: Spigelman fullname: Spigelman, Mark organization: Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London – sequence: 10 givenname: Nicholas J. surname: Loman fullname: Loman, Nicholas J. organization: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham – sequence: 11 givenname: Mark surname: Achtman fullname: Achtman, Mark organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road – sequence: 12 givenname: Helen D. surname: Donoghue fullname: Donoghue, Helen D. organization: Division of Infection and Immunity, Centre for Clinical Microbiology, University College London – sequence: 13 givenname: Mark J. surname: Pallen fullname: Pallen, Mark J. email: m.pallen@warwick.ac.uk organization: Division of Translational and Systems Medicine, Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25848958$$D View this record in MEDLINE/PubMed
BookMark	eNptkU1P3DAQhq2KqnyUS38AssSlokrrsb35uFSq0PZDQuqFni2vM9mYJvZiOwX-PY4W6Jbigz3SPPPOO55Dsue8Q0LeAfsITNSfnPHjGKsKqlfkgDMJBVRc7O3E--Q4xiuWj2iglvIN2eeLWtbNoj4g_dKu-4ToUl-YfE_hjq7R-REjjb2_oanXiY72FltqXYcmWe8ivcGAdO7sHc35ZEekvqMb1L9pmlYYzDT4aGOuocsp-A2-Ja87PUQ8fniPyK-vy8vz78XFz28_zr9cFEZKngrNdFcvWNlKqUVTcYmi7tiKaQPYGGzBgOBVIxFWvGWlbjVmuATdgCnbWooj8nmru5lWI7bzTEEPahPsqMOd8tqqfzPO9mrt_ygpmlKUIgu8fxAI_nrCmNRoo8Fh0A79FBWUFWcNVGLudfoMvfJTcHm8mWIcQJaQqZNdR09WHpeQAbYFTPAxBuyUsUnPH50N2kEBU_Oq1d9V55KzZyWPqi_CH7ZwzJBbY9ix-T99D3GuvAE
CitedBy_id	crossref_primary_10_1038_nm_4205 crossref_primary_10_1080_24745332_2024_2366310 crossref_primary_10_1128_JCM_00923_18 crossref_primary_10_1073_pnas_1807266115 crossref_primary_10_1016_j_tube_2020_102037 crossref_primary_10_1093_femsre_fuae006 crossref_primary_10_1093_cid_ciz790 crossref_primary_10_3390_v16060953 crossref_primary_10_1111_tbed_14343 crossref_primary_10_1016_j_coi_2021_04_006 crossref_primary_10_1038_ng_3704 crossref_primary_10_3390_d9040046 crossref_primary_10_1038_s41598_018_29620_2 crossref_primary_10_1002_evan_21970 crossref_primary_10_2147_IDR_S480621 crossref_primary_10_1016_j_tim_2016_03_007 crossref_primary_10_1038_s41579_025_01159_w crossref_primary_10_1073_pnas_1611283113 crossref_primary_10_1016_j_tube_2023_102453 crossref_primary_10_1128_CMR_00055_15 crossref_primary_10_1016_S1473_3099_15_00071_7 crossref_primary_10_1073_pnas_1820447116 crossref_primary_10_1128_microbiolspec_TBTB2_0008_2016 crossref_primary_10_1016_j_jas_2016_01_003 crossref_primary_10_1016_j_meegid_2018_07_040 crossref_primary_10_1111_sji_12567 crossref_primary_10_1186_s13059_019_1903_0 crossref_primary_10_1016_j_ijpp_2019_12_006 crossref_primary_10_1038_s41576_019_0119_1 crossref_primary_10_1371_journal_pone_0184510 crossref_primary_10_1371_journal_pone_0185966 crossref_primary_10_3390_antibiotics14040416 crossref_primary_10_1093_femsre_fuac008 crossref_primary_10_3389_fmicb_2020_00843 crossref_primary_10_1016_j_tube_2023_102387 crossref_primary_10_1186_s12864_018_5162_3 crossref_primary_10_1016_j_cub_2018_05_058 crossref_primary_10_1016_j_biotechadv_2020_107572 crossref_primary_10_1038_s42003_023_05388_8 crossref_primary_10_1038_s41598_017_01501_0 crossref_primary_10_1146_annurev_genom_021623_101844 crossref_primary_10_1128_microbiolspec_PoH_0003_2014 crossref_primary_10_1177_0959683619895572 crossref_primary_10_1016_j_tube_2023_102392 crossref_primary_10_1016_j_tube_2020_101995 crossref_primary_10_1016_j_tube_2023_102396 crossref_primary_10_1016_j_ijid_2020_11_195 crossref_primary_10_1017_aaq_2020_94 crossref_primary_10_1111_1755_0998_12546 crossref_primary_10_1099_mgen_0_000094 crossref_primary_10_1038_s41437_020_00377_7 crossref_primary_10_1038_s41559_018_0680_6 crossref_primary_10_1038_s41598_019_56001_0 crossref_primary_10_1038_nrmicro_2018_8 crossref_primary_10_1371_journal_ppat_1008067 crossref_primary_10_1016_j_ijpp_2019_05_005 crossref_primary_10_1093_femspd_ftx020 crossref_primary_10_1093_infdis_jiad249 crossref_primary_10_1080_03014460_2019_1624822 crossref_primary_10_1007_s10096_015_2427_5 crossref_primary_10_1177_0959683619857230 crossref_primary_10_1016_j_ijmyco_2016_11_028 crossref_primary_10_1016_j_tube_2017_09_004 crossref_primary_10_1111_1556_4029_13138 crossref_primary_10_1186_s13059_024_03405_5 crossref_primary_10_1038_nrmicro3565 crossref_primary_10_1016_j_ajhg_2021_02_009 crossref_primary_10_1016_j_ijmm_2020_151399 crossref_primary_10_1093_molbev_msaa179 crossref_primary_10_1016_j_ijpp_2024_11_001 crossref_primary_10_1016_j_tube_2023_102371 crossref_primary_10_3389_fgene_2020_600692 crossref_primary_10_1099_mgen_0_000384 crossref_primary_10_1038_s42003_025_08383_3 crossref_primary_10_3390_epidemiologia3040034 crossref_primary_10_1016_j_tube_2023_102368 crossref_primary_10_1093_gigascience_giz065 crossref_primary_10_1371_journal_pone_0170353 crossref_primary_10_1371_journal_pone_0173464 crossref_primary_10_1073_pnas_1603224113 crossref_primary_10_1146_annurev_micro_090817_062436 crossref_primary_10_1016_j_jas_2018_07_011 crossref_primary_10_1128_msystems_00427_25 crossref_primary_10_1186_s13073_025_01430_y crossref_primary_10_1016_j_actatropica_2015_09_002 crossref_primary_10_1038_s41559_018_0732_y crossref_primary_10_1186_s13073_024_01289_5 crossref_primary_10_1093_ve_vead087 crossref_primary_10_1038_s41598_024_64818_7 crossref_primary_10_3390_pathogens11050584 crossref_primary_10_1016_j_meegid_2018_12_013 crossref_primary_10_1016_j_tube_2022_102181 crossref_primary_10_1186_s13059_020_02112_1 crossref_primary_10_1134_S0006297922030051 crossref_primary_10_1099_mgen_0_000326 crossref_primary_10_1016_j_tim_2016_08_004 crossref_primary_10_1016_j_ijid_2016_11_413 crossref_primary_10_1128_JCM_02664_15 crossref_primary_10_1038_s41564_024_01758_y crossref_primary_10_1016_j_jinf_2022_05_011 crossref_primary_10_1016_j_tube_2016_08_002 crossref_primary_10_1093_infdis_jix298 crossref_primary_10_1093_sysbio_syw059 crossref_primary_10_3389_fcimb_2022_954074 crossref_primary_10_1111_mec_15120 crossref_primary_10_1186_s12864_018_4988_z crossref_primary_10_1186_s12915_017_0433_z crossref_primary_10_1080_03014460_2017_1346709 crossref_primary_10_24072_pcjournal_322
Cites_doi	10.1002/ajpa.10114 10.1371/journal.pone.0065012 10.1038/ng.2744 10.1186/1471-2105-14-85 10.1056/NEJMc1302295 10.1038/44766 10.1371/journal.pcbi.1003549 10.1093/bioinformatics/btp352 10.1038/nature13591 10.1371/journal.pone.0078252 10.1371/journal.pone.0070178 10.1128/JCM.42.12.5528-5536.2004 10.1016/j.tim.2013.07.007 10.1164/rccm.200305-714OC 10.1099/mic.0.25961-0 10.1073/pnas.0511240103 10.1093/molbev/msi103 10.1093/bioinformatics/btl446 10.1038/ncomms5812 10.1016/S1473-3099(07)70108-1 10.1093/ije/dyh196 10.1016/j.tube.2014.02.005 10.1093/bioinformatics/bts544 10.1017/S0031182014000134 10.1093/bioinformatics/btg412 10.1016/j.meegid.2012.02.010 10.1038/ng.2878 10.1371/journal.pone.0003426 10.1056/NEJMc1311596 10.1099/mic.0.26662-0 10.1016/S1473-3099(12)70277-3 10.7717/peerj.585 10.1093/bioinformatics/btt193 10.1016/j.meegid.2007.06.003 10.1086/321886 10.1002/ajpa.22137 10.1126/science.1238286 10.1098/rspb.2013.3236 10.1186/1471-2334-13-110 10.1016/S0065-308X(03)54008-8 10.1038/nmeth.1923 10.1093/molbev/mss075 10.1017/S0022172400002965
ContentType	Journal Article
Copyright	The Author(s) 2015 Copyright Nature Publishing Group Apr 2015 Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Copyright_xml	– notice: The Author(s) 2015 – notice: Copyright Nature Publishing Group Apr 2015 – notice: Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM
DOI	10.1038/ncomms7717
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection PML(ProQuest Medical Library) Biological Science Database Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Databases ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	CrossRef Publicly Available Content Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2041-1723
EndPage	6717
ExternalDocumentID	PMC4396363 3646923531 25848958 10_1038_ncomms7717
Genre	Historical Article Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Hungary Europe
GeographicLocations_xml	– name: Europe – name: Hungary
GrantInformation_xml	– fundername: Medical Research Council grantid: MR/M501621/1 – fundername: Wellcome Trust grantid: 0516/Z/97/Z – fundername: Medical Research Council grantid: G0901717 – fundername: Wellcome Trust – fundername: Biotechnology and Biological Sciences Research Council grantid: BB/L020319/1 – fundername: Medical Research Council grantid: MR/J014370/1
GroupedDBID	--- 0R~ 39C 3V. 4.4 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABAWZ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BAPOH BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EJD EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM
ID	FETCH-LOGICAL-c442t-a0af8506d44a39724e38f0b0ac1e9ced1c132794e1b2d06adae06d61a91c6d843
IEDL.DBID	M7P
ISICitedReferencesCount	132
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000353701300002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2041-1723
IngestDate	Tue Nov 04 01:57:07 EST 2025 Thu Oct 02 12:40:44 EDT 2025 Sat Nov 29 14:25:43 EST 2025 Mon Jul 21 05:57:16 EDT 2025 Tue Nov 18 22:53:27 EST 2025 Sat Nov 29 03:46:03 EST 2025 Fri Feb 21 02:39:39 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Language	English
License	This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c442t-a0af8506d44a39724e38f0b0ac1e9ced1c132794e1b2d06adae06d61a91c6d843
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work
OpenAccessLink	https://www.proquest.com/docview/1670211461?pq-origsite=%requestingapplication%
PMID	25848958
PQID	1670211461
PQPubID	546298
PageCount	1
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_4396363 proquest_miscellaneous_1672091734 proquest_journals_1670211461 pubmed_primary_25848958 crossref_citationtrail_10_1038_ncomms7717 crossref_primary_10_1038_ncomms7717 springer_journals_10_1038_ncomms7717
PublicationCentury	2000
PublicationDate	20150407
PublicationDateYYYYMMDD	2015-04-07
PublicationDate_xml	– month: 4 year: 2015 text: 20150407 day: 7
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Nature communications
PublicationTitleAbbrev	Nat Commun
PublicationTitleAlternate	Nat Commun
PublicationYear	2015
Publisher	Nature Publishing Group UK Nature Publishing Group Nature Pub. Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Pub. Group
References	Bykova, Favorov, Mironov (CR41) 2013; 8 Coll (CR15) 2014; 5 Coll (CR14) 2014; 94 Worby, Lipsitch, Hanage (CR30) 2014; 10 Shabbeer (CR43) 2012; 12 Comas (CR2) 2013; 45 Schuenemann (CR7) 2013; 341 Baele, Lemey, Vansteelandt (CR44) 2013; 14 Warren (CR26) 2004; 169 Casali (CR12) 2014; 46 Muller, Roberts, Brown (CR18) 2014; 281 Gagneux, Small (CR10) 2007; 7 Drummond, Rambaut, Shapiro, Pybus (CR21) 2005; 22 Masson (CR31) 2013; 8 Hanekom (CR25) 2013; 8 Newsholme (CR20) 1906; 6 Kodmon (CR32) 2007; 7 Jonsson, Ginolhac, Schubert, Johnson, Orlando (CR36) 2013; 29 Donoghue (CR4) 2013; 21 Doughty, Sergeant, Adetifa, Antonio, Pallen (CR29) 2014; 2 Walker (CR13) 2013; 13 Drummond, Pybus, Rambaut (CR16) 2003; 54 Marmiesse (CR9) 2004; 150 Nicklisch (CR23) 2012; 149 Shamputa (CR27) 2004; 42 Koch (CR1) 1882; 19 Bryant (CR11) 2013; 13 Fletcher, Donoghue, Holton, Pap, Spigelman (CR6) 2003; 120 Langmead, Salzberg (CR35) 2012; 9 Coll (CR42) 2012; 28 Stamatakis (CR38) 2006; 22 Bos (CR3) 2014; 514 Wilson (CR19) 2005; 34 Rothschild (CR22) 2001; 33 Pagel (CR39) 1999; 401 Gagneux (CR8) 2006; 103 Drummond, Suchard, Xie, Rambaut (CR17) 2012; 29 Hershkovitz (CR24) 2008; 3 Li (CR37) 2009; 25 Fletcher, Donoghue, Taylor, van der Zanden, Spigelman (CR34) 2003; 149 Chan (CR5) 2013; 369 Hingley-Wilson (CR28) 2013; 369 Pallen (CR33) 2014; 141 Paradis, Claude, Strimmer (CR40) 2004; 20 C Kodmon (BFncomms7717_CR32) 2007; 7 N Nicklisch (BFncomms7717_CR23) 2012; 149 A Drummond (BFncomms7717_CR16) 2003; 54 H Li (BFncomms7717_CR37) 2009; 25 AJ Drummond (BFncomms7717_CR17) 2012; 29 A Stamatakis (BFncomms7717_CR38) 2006; 22 F Coll (BFncomms7717_CR15) 2014; 5 M Pagel (BFncomms7717_CR39) 1999; 401 EL Doughty (BFncomms7717_CR29) 2014; 2 MJ Pallen (BFncomms7717_CR33) 2014; 141 F Coll (BFncomms7717_CR42) 2012; 28 R Muller (BFncomms7717_CR18) 2014; 281 M Marmiesse (BFncomms7717_CR9) 2004; 150 BM Rothschild (BFncomms7717_CR22) 2001; 33 RM Warren (BFncomms7717_CR26) 2004; 169 M Masson (BFncomms7717_CR31) 2013; 8 JZ Chan (BFncomms7717_CR5) 2013; 369 SM Hingley-Wilson (BFncomms7717_CR28) 2013; 369 KI Bos (BFncomms7717_CR3) 2014; 514 AJ Drummond (BFncomms7717_CR21) 2005; 22 TM Walker (BFncomms7717_CR13) 2013; 13 N Casali (BFncomms7717_CR12) 2014; 46 HA Fletcher (BFncomms7717_CR6) 2003; 120 S Gagneux (BFncomms7717_CR10) 2007; 7 B Langmead (BFncomms7717_CR35) 2012; 9 A Shabbeer (BFncomms7717_CR43) 2012; 12 E Paradis (BFncomms7717_CR40) 2004; 20 VJ Schuenemann (BFncomms7717_CR7) 2013; 341 HA Fletcher (BFncomms7717_CR34) 2003; 149 I Hershkovitz (BFncomms7717_CR24) 2008; 3 NA Bykova (BFncomms7717_CR41) 2013; 8 LG Wilson (BFncomms7717_CR19) 2005; 34 JM Bryant (BFncomms7717_CR11) 2013; 13 H Jonsson (BFncomms7717_CR36) 2013; 29 R Koch (BFncomms7717_CR1) 1882; 19 HD Donoghue (BFncomms7717_CR4) 2013; 21 G Baele (BFncomms7717_CR44) 2013; 14 A Newsholme (BFncomms7717_CR20) 1906; 6 M Hanekom (BFncomms7717_CR25) 2013; 8 F Coll (BFncomms7717_CR14) 2014; 94 CJ Worby (BFncomms7717_CR30) 2014; 10 IC Shamputa (BFncomms7717_CR27) 2004; 42 I Comas (BFncomms7717_CR2) 2013; 45 S Gagneux (BFncomms7717_CR8) 2006; 103
References_xml	– volume: 120 start-page: 144 year: 2003 end-page: 152 ident: CR6 article-title: Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians publication-title: Am. J. Phys. Anthropol. doi: 10.1002/ajpa.10114 – volume: 8 start-page: e65012 year: 2013 ident: CR41 article-title: Hidden Markov models for evolution and comparative genomics analysis publication-title: PLoS ONE doi: 10.1371/journal.pone.0065012 – volume: 45 start-page: 1176 year: 2013 end-page: 1182 ident: CR2 article-title: Out-of-Africa migration and Neolithic coexpansion of with modern humans publication-title: Nature Genet. doi: 10.1038/ng.2744 – volume: 14 start-page: 85 year: 2013 ident: CR44 article-title: Make the most of your samples: Bayes factor estimators for high-dimensional models of sequence evolution publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-14-85 – volume: 369 start-page: 289 year: 2013 end-page: 290 ident: CR5 article-title: Metagenomic analysis of tuberculosis in a mummy publication-title: N. Engl. J. Med. doi: 10.1056/NEJMc1302295 – volume: 401 start-page: 877 year: 1999 end-page: 884 ident: CR39 article-title: Inferring the historical patterns of biological evolution publication-title: Nature doi: 10.1038/44766 – volume: 10 start-page: e1003549 year: 2014 ident: CR30 article-title: Within-host bacterial diversity hinders accurate reconstruction of transmission networks from genomic distance data publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1003549 – volume: 25 start-page: 2078 year: 2009 end-page: 2079 ident: CR37 article-title: The Sequence Alignment/Map format and SAMtools publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 514 start-page: 494 year: 2014 end-page: 497 ident: CR3 article-title: Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis publication-title: Nature doi: 10.1038/nature13591 – volume: 8 start-page: e78252 year: 2013 ident: CR31 article-title: Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary publication-title: PLoS ONE doi: 10.1371/journal.pone.0078252 – volume: 8 start-page: e70178 year: 2013 ident: CR25 article-title: Population structure of mixed Mycobacterium tuberculosis infection is strain genotype and culture medium dependent publication-title: PLoS ONE doi: 10.1371/journal.pone.0070178 – volume: 42 start-page: 5528 year: 2004 end-page: 5536 ident: CR27 article-title: Genotypic and phenotypic heterogeneity among Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.42.12.5528-5536.2004 – volume: 21 start-page: 448 year: 2013 end-page: 450 ident: CR4 article-title: Insights into ancient leprosy and tuberculosis using metagenomics publication-title: Trends Microbiol. doi: 10.1016/j.tim.2013.07.007 – volume: 169 start-page: 610 year: 2004 end-page: 614 ident: CR26 article-title: Patients with active tuberculosis often have different strains in the same sputum specimen publication-title: Am. J. Respir. Crit. Care. Med. doi: 10.1164/rccm.200305-714OC – volume: 149 start-page: 143 year: 2003 end-page: 151 ident: CR34 article-title: Molecular analysis of DNA from a family of 18th century Hungarians publication-title: Microbiology doi: 10.1099/mic.0.25961-0 – volume: 103 start-page: 2869 year: 2006 end-page: 2873 ident: CR8 article-title: Variable host–pathogen compatibility in Mycobacterium tuberculosis publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0511240103 – volume: 22 start-page: 1185 year: 2005 end-page: 1192 ident: CR21 article-title: Bayesian coalescent inference of past population dynamics from molecular sequences publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msi103 – volume: 22 start-page: 2688 year: 2006 end-page: 2690 ident: CR38 article-title: RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl446 – volume: 5 start-page: 4812 year: 2014 ident: CR15 article-title: A robust SNP barcode for typing Mycobacterium tuberculosis complex strains publication-title: Nat. Commun. doi: 10.1038/ncomms5812 – volume: 7 start-page: 328 year: 2007 end-page: 337 ident: CR10 article-title: Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(07)70108-1 – volume: 34 start-page: 521 year: 2005 end-page: 524 ident: CR19 article-title: Commentary: Medicine, population, and tuberculosis publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyh196 – volume: 94 start-page: 346 year: 2014 end-page: 354 ident: CR14 article-title: PolyTB: A genomic variation map for Mycobacterium tuberculosis publication-title: Tuberculosis (Edinb) doi: 10.1016/j.tube.2014.02.005 – volume: 28 start-page: 2991 year: 2012 end-page: 2993 ident: CR42 article-title: SpolPred: rapid and accurate prediction of Mycobacterium tuberculosis spoligotypes from short genomic sequences publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts544 – volume: 141 start-page: 1 year: 2014 end-page: 7 ident: CR33 article-title: Diagnostic metagenomics: potential applications to bacterial, viral and parasitic infections publication-title: Parasitology doi: 10.1017/S0031182014000134 – volume: 20 start-page: 289 year: 2004 end-page: 290 ident: CR40 article-title: APE: Analyses of Phylogenetics and Evolution in R language publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg412 – volume: 12 start-page: 789 year: 2012 end-page: 797 ident: CR43 article-title: TB-Lineage: an online tool for classification and analysis of strains of Mycobacterium tuberculosis complex publication-title: Infect. Genet. Evol. doi: 10.1016/j.meegid.2012.02.010 – volume: 46 start-page: 279 year: 2014 end-page: 286 ident: CR12 article-title: Evolution and transmission of drug-resistant tuberculosis in a Russian population publication-title: Nature Genet. doi: 10.1038/ng.2878 – volume: 3 start-page: e3426 year: 2008 ident: CR24 article-title: Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean publication-title: PLoS ONE doi: 10.1371/journal.pone.0003426 – volume: 369 start-page: 1572 year: 2013 ident: CR28 article-title: Metagenomic analysis of tuberculosis--current limitations publication-title: N. Engl. J. Med. doi: 10.1056/NEJMc1311596 – volume: 150 start-page: 483 year: 2004 end-page: 496 ident: CR9 article-title: Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex publication-title: Microbiology. doi: 10.1099/mic.0.26662-0 – volume: 13 start-page: 137 year: 2013 end-page: 146 ident: CR13 article-title: Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(12)70277-3 – volume: 2 start-page: e585 year: 2014 ident: CR29 article-title: Culture-independent detection and characterisation of Mycobacterium tuberculosis and M. africanum in sputum samples using shotgun metagenomics on a benchtop sequencer publication-title: PeerJ doi: 10.7717/peerj.585 – volume: 29 start-page: 1682 year: 2013 end-page: 1684 ident: CR36 article-title: mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt193 – volume: 7 start-page: 632 year: 2007 end-page: 635 ident: CR32 article-title: Molecular clues of a microepidemy among homeless tuberculosis patients in Budapest due to a new and local Mycobacterium tuberculosis clade publication-title: Infect. Genet. Evol. doi: 10.1016/j.meegid.2007.06.003 – volume: 19 start-page: 221 year: 1882 end-page: 230 ident: CR1 article-title: Die Aetiologie der Tuberkulose publication-title: Berl. Klin. Wochenschr. – volume: 33 start-page: 305 year: 2001 end-page: 311 ident: CR22 article-title: complex DNA from an extinct bison dated 17,000 years before the present publication-title: Clin. Infect. Dis. doi: 10.1086/321886 – volume: 149 start-page: 391 year: 2012 end-page: 404 ident: CR23 article-title: Rib lesions in skeletons from early neolithic sites in Central Germany: on the trail of tuberculosis at the onset of agriculture publication-title: Am. J. Phys. Anthropol. doi: 10.1002/ajpa.22137 – volume: 341 start-page: 179 year: 2013 end-page: 183 ident: CR7 article-title: Genome-wide comparison of medieval and modern publication-title: Science doi: 10.1126/science.1238286 – volume: 281 start-page: 20133236 year: 2014 ident: CR18 article-title: Genotyping of ancient Mycobacterium tuberculosis strains reveals historic genetic diversity publication-title: Proc. Biol. Sci. doi: 10.1098/rspb.2013.3236 – volume: 13 start-page: 110 year: 2013 ident: CR11 article-title: Inferring patient to patient transmission of Mycobacterium tuberculosis from whole genome sequencing data publication-title: BMC Infect. Dis. doi: 10.1186/1471-2334-13-110 – volume: 54 start-page: 331 year: 2003 end-page: 358 ident: CR16 article-title: Inference of viral evolutionary rates from molecular sequences publication-title: Adv. Parasitol. doi: 10.1016/S0065-308X(03)54008-8 – volume: 9 start-page: 357 year: 2012 end-page: 359 ident: CR35 article-title: Fast gapped-read alignment with Bowtie 2 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 29 start-page: 1969 year: 2012 end-page: 1973 ident: CR17 article-title: Bayesian phylogenetics with BEAUti and the BEAST 1.7 publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/mss075 – volume: 6 start-page: 304 year: 1906 end-page: 384 ident: CR20 article-title: An inquiry into the principal causes of the reduction in the death-rate from phthisis during the last forty years, with special reference to the segregation of phthisical patients in general institutions publication-title: J. Hyg. doi: 10.1017/S0022172400002965 – volume: 46 start-page: 279 year: 2014 ident: BFncomms7717_CR12 publication-title: Nature Genet. doi: 10.1038/ng.2878 – volume: 8 start-page: e78252 year: 2013 ident: BFncomms7717_CR31 publication-title: PLoS ONE doi: 10.1371/journal.pone.0078252 – volume: 29 start-page: 1969 year: 2012 ident: BFncomms7717_CR17 publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/mss075 – volume: 25 start-page: 2078 year: 2009 ident: BFncomms7717_CR37 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp352 – volume: 9 start-page: 357 year: 2012 ident: BFncomms7717_CR35 publication-title: Nat. Methods doi: 10.1038/nmeth.1923 – volume: 8 start-page: e70178 year: 2013 ident: BFncomms7717_CR25 publication-title: PLoS ONE doi: 10.1371/journal.pone.0070178 – volume: 34 start-page: 521 year: 2005 ident: BFncomms7717_CR19 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyh196 – volume: 28 start-page: 2991 year: 2012 ident: BFncomms7717_CR42 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts544 – volume: 341 start-page: 179 year: 2013 ident: BFncomms7717_CR7 publication-title: Science doi: 10.1126/science.1238286 – volume: 103 start-page: 2869 year: 2006 ident: BFncomms7717_CR8 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0511240103 – volume: 149 start-page: 391 year: 2012 ident: BFncomms7717_CR23 publication-title: Am. J. Phys. Anthropol. doi: 10.1002/ajpa.22137 – volume: 22 start-page: 2688 year: 2006 ident: BFncomms7717_CR38 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl446 – volume: 120 start-page: 144 year: 2003 ident: BFncomms7717_CR6 publication-title: Am. J. Phys. Anthropol. doi: 10.1002/ajpa.10114 – volume: 94 start-page: 346 year: 2014 ident: BFncomms7717_CR14 publication-title: Tuberculosis (Edinb) doi: 10.1016/j.tube.2014.02.005 – volume: 514 start-page: 494 year: 2014 ident: BFncomms7717_CR3 publication-title: Nature doi: 10.1038/nature13591 – volume: 150 start-page: 483 year: 2004 ident: BFncomms7717_CR9 publication-title: Microbiology. doi: 10.1099/mic.0.26662-0 – volume: 20 start-page: 289 year: 2004 ident: BFncomms7717_CR40 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg412 – volume: 10 start-page: e1003549 year: 2014 ident: BFncomms7717_CR30 publication-title: PLoS Comput. Biol. doi: 10.1371/journal.pcbi.1003549 – volume: 281 start-page: 20133236 year: 2014 ident: BFncomms7717_CR18 publication-title: Proc. Biol. Sci. doi: 10.1098/rspb.2013.3236 – volume: 7 start-page: 328 year: 2007 ident: BFncomms7717_CR10 publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(07)70108-1 – volume: 3 start-page: e3426 year: 2008 ident: BFncomms7717_CR24 publication-title: PLoS ONE doi: 10.1371/journal.pone.0003426 – volume: 369 start-page: 1572 year: 2013 ident: BFncomms7717_CR28 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMc1311596 – volume: 8 start-page: e65012 year: 2013 ident: BFncomms7717_CR41 publication-title: PLoS ONE doi: 10.1371/journal.pone.0065012 – volume: 19 start-page: 221 year: 1882 ident: BFncomms7717_CR1 publication-title: Berl. Klin. Wochenschr. – volume: 54 start-page: 331 year: 2003 ident: BFncomms7717_CR16 publication-title: Adv. Parasitol. doi: 10.1016/S0065-308X(03)54008-8 – volume: 33 start-page: 305 year: 2001 ident: BFncomms7717_CR22 publication-title: Clin. Infect. Dis. doi: 10.1086/321886 – volume: 149 start-page: 143 year: 2003 ident: BFncomms7717_CR34 publication-title: Microbiology doi: 10.1099/mic.0.25961-0 – volume: 141 start-page: 1 year: 2014 ident: BFncomms7717_CR33 publication-title: Parasitology doi: 10.1017/S0031182014000134 – volume: 2 start-page: e585 year: 2014 ident: BFncomms7717_CR29 publication-title: PeerJ doi: 10.7717/peerj.585 – volume: 21 start-page: 448 year: 2013 ident: BFncomms7717_CR4 publication-title: Trends Microbiol. doi: 10.1016/j.tim.2013.07.007 – volume: 5 start-page: 4812 year: 2014 ident: BFncomms7717_CR15 publication-title: Nat. Commun. doi: 10.1038/ncomms5812 – volume: 42 start-page: 5528 year: 2004 ident: BFncomms7717_CR27 publication-title: J. Clin. Microbiol. doi: 10.1128/JCM.42.12.5528-5536.2004 – volume: 22 start-page: 1185 year: 2005 ident: BFncomms7717_CR21 publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msi103 – volume: 29 start-page: 1682 year: 2013 ident: BFncomms7717_CR36 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt193 – volume: 12 start-page: 789 year: 2012 ident: BFncomms7717_CR43 publication-title: Infect. Genet. Evol. doi: 10.1016/j.meegid.2012.02.010 – volume: 13 start-page: 110 year: 2013 ident: BFncomms7717_CR11 publication-title: BMC Infect. Dis. doi: 10.1186/1471-2334-13-110 – volume: 6 start-page: 304 year: 1906 ident: BFncomms7717_CR20 publication-title: J. Hyg. doi: 10.1017/S0022172400002965 – volume: 401 start-page: 877 year: 1999 ident: BFncomms7717_CR39 publication-title: Nature doi: 10.1038/44766 – volume: 45 start-page: 1176 year: 2013 ident: BFncomms7717_CR2 publication-title: Nature Genet. doi: 10.1038/ng.2744 – volume: 7 start-page: 632 year: 2007 ident: BFncomms7717_CR32 publication-title: Infect. Genet. Evol. doi: 10.1016/j.meegid.2007.06.003 – volume: 14 start-page: 85 year: 2013 ident: BFncomms7717_CR44 publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-14-85 – volume: 13 start-page: 137 year: 2013 ident: BFncomms7717_CR13 publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(12)70277-3 – volume: 369 start-page: 289 year: 2013 ident: BFncomms7717_CR5 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMc1302295 – volume: 169 start-page: 610 year: 2004 ident: BFncomms7717_CR26 publication-title: Am. J. Respir. Crit. Care. Med. doi: 10.1164/rccm.200305-714OC
SSID	ssj0000391844
Score	2.524688
Snippet	Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here... Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at 'peak TB' relate to what we see today. Here... Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB' relate to what we see today. Here...
SourceID	pubmedcentral proquest pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	6717
SubjectTerms	631/208/212/2142 631/208/212/2304 631/326/41/1470 692/699/255/1856 Adult Bayes Theorem Coinfection - microbiology DNA, Bacterial - analysis Europe - epidemiology Female Genome, Bacterial - genetics Genotype Genotypes History, 18th Century Humanities and Social Sciences Humans Hungary - epidemiology Male Metagenomics Middle Aged Molecular Epidemiology multidisciplinary Mycobacterium tuberculosis - genetics Phylogeny Science Science (multidisciplinary) Tuberculosis Tuberculosis - epidemiology Tuberculosis - history Tuberculosis - microbiology Young Adult
Title	Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe
URI	https://link.springer.com/article/10.1038/ncomms7717 https://www.ncbi.nlm.nih.gov/pubmed/25848958 https://www.proquest.com/docview/1670211461 https://www.proquest.com/docview/1672091734 https://pubmed.ncbi.nlm.nih.gov/PMC4396363
Volume	6
WOSCitedRecordID	wos000353701300002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RFiQuvAuhZWVELxyi5uHYzgmVaiuQYBUhkBYukeM4yopusmyyFP49Y-fRxyIuXHKZceLIHs_nmdE3AEfCQ1ChGXVjFoWu4S93hVSmxIoqX8oCPbAlcf3AZzMxn8dJH3Br-rLK4Uy0B3VeKxMjP_YZR3dkulC_Wf1wTdcok13tW2jswJ5hSQhs6V4yxlgM-7mgdGAlDcVxha9cNpzb_mRX_NAWuNyukbyRKLX-5-z-_878AdzrkSc56bbKQ7ilq0dwp-tF-fsxlFNzTTd1FaWrOk9EDIHrUjekKesL0payJcvFL52ToYKrasiFXmtifreuCMpNq3pSF2Sl5XfSbjK9Vpvzulk0OIZ0kf8n8OVs-vn0ndu3YXAVpUHrSk8Whtcup1QiegmoDkXhZZ5Uvo6Vzn2FN1o0a-1nQe4xmUuNysyXsa9YLmi4D7tVXelnQBCO0IwzU1pXUI0DaJTRIs98nSlPxoEDr4dFSVXPUW5aZZynNlceivRyAR14NequOmaOv2odDouS9tbZpJcr4sDLUYx2ZZIlstL1xuoEiKV4SB142m2F8TMBojYRR8IBfm2TjAqGs_u6pFqUlrsb8R8LWejA0bCdrkxra_bP_z37A7iL-C2yhUT8EHbb9Ua_gNvqZ7to1hPY4XNun2ICe2-ns-TTxIYcJtZK8JlE31CSvP-YfP0DMj4fig
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VLQguvCmBAkaUA4eoeXgT54AQglZddbvaQ5HKKTjORInoJttNlqV_it_IOK-2LOLWA2ePE9v5PDP2TL4B2BEWORXocTPwhq6p-ctNIZVOseLKljIhC1yTuI79yUScnATTDfjV_Quj0yo7nVgr6rhQ-o581_Z8Mke6CvWH-Zmpq0bp6GpXQqOBxSGer-jIVr4ffabv-9Zx9veOPx2YbVUBU3HuVKa0ZKJp2mLOJRljh6MrEiuypLIxUBjbig5ohFK0Iye2PBlLJGHPloGtvFhwl557Aza5BvsANqejo-nX_lZH860LzjseVFfs5jSJWen7dUW0S5ZvzZ1dz8r8IzRbW7z9e__bWt2Hu61vzT42m-EBbGD-EG411TbPH0G6py8idOZIaqrG1jJNUTvDkpVpsWJVKis2y35izLoctbxkK1wg08tb5Izaq2yGrEjYHOV3Vi0jXKjlaVFmJfVhTWzjMXy5lmk-gUFe5PgUGDlcPPI9nTyYcKQOfBjxJI5sjJQlA8eAdx0IQtWysOtiIKdhnQ3givACMAa86WXnDffIX6W2OxCErf4pwwsEGPC6bybNocNBMsdiWcs45C36Ljdgq4Fe_xqH_FIRDIUB_hVQ9gKalfxqS56lNTs5ebie67kG7HTwvTSstdE_-_foX8Htg-OjcTgeTQ6fwx3yVod12pS_DYNqscQXcFP9qLJy8bLdiQy-XTegfwOMPHdh
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8hAX3o_QAkaUA4do83AS54AqRLuiarXaA0gVl-A4EyWimyybLNv-tf46xnm1ZRG3Hjh7nNjOZ8_Y_vINwI6wKKhAn5uh77mm1i83hVSaYsWVLWVKHrgRcT0KJhNxfBxON-C8_xdG0yr7NbFZqJNS6TPyke0H5I50FupR2tEipnvj3flPU2eQ0jetfTqNFiKHeLai7Vv14WCPvvU7xxnvf_n02ewyDJiKc6c2pSVTLdmWcC7JMTscXZFasSWVjaHCxFa0WSPEoh07ieXLRCIZ-7YMbeUngrv03BtwM6A9pqYTTr1vw_mOVl4XnPeKqK4YFdSdWRUETW60Sz5wLbBd52f-cUnb-L7x_f951B7AvS7iZh_bKfIQNrB4BLfbHJxnjyHb18cTmk-Smar1wEwL186wYlVWrlidyZrN8lNMWM9cKyq2wgUyPdRlwai8zmfIypTNUf5g9TLGhVqelFVeUR3W3ng8ga_X0s2nsFmUBT4HRmEYjwNfUwpTjlSBezFPk9jGWFkydAx43wMiUp02u04RchI1HAFXRBfgMeDtYDtvFUn-arXdAyLqVqUqukCDAW-GYlpP9CWRLLBcNjYOxZCByw141sJweI1D0aoIPWFAcAWgg4HWKr9aUuRZo1lOca_v-q4BOz2ULzVrrfUv_t3613CHUBwdHUwOt-AuhbBew6UKtmGzXizxJdxSv-q8WrxqpiSD79eN5t9Zvn7E
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Eighteenth-century+genomes+show+that+mixed+infections+were+common+at+time+of+peak+tuberculosis+in+Europe&rft.jtitle=Nature+communications&rft.au=Kay%2C+Gemma+L&rft.au=Sergeant%2C+Martin+J&rft.au=Zhou%2C+Zhemin&rft.au=Chan%2C+Jacqueline+Z-M&rft.date=2015-04-07&rft.eissn=2041-1723&rft.volume=6&rft.spage=6717&rft_id=info:doi/10.1038%2Fncomms7717&rft_id=info%3Apmid%2F25848958&rft.externalDocID=25848958
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon