Pramel7 mediates ground-state pluripotency through proteasomal–epigenetic combined pathways

Naive pluripotency is established in preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of naive pluripotency. 2i culture has optimized this state, leading to a gene signature and DNA hypomethylation closely comparable to preimplantation epiblast, the developmental g...

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Veröffentlicht in:	Nature cell biology Jg. 19; H. 7; S. 763 - 773
Hauptverfasser:	Graf, Urs, Casanova, Elisa A., Wyck, Sarah, Dalcher, Damian, Gatti, Marco, Vollenweider, Eva, Okoniewski, Michal J., Weber, Fabienne A., Patel, Sameera S., Schmid, Marc W., Li, Jiwen, Sharif, Jafar, Wanner, Guido A., Koseki, Haruhiko, Wong, Jiemin, Pelczar, Pawel, Penengo, Lorenza, Santoro, Raffaella, Cinelli, Paolo
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.07.2017 Nature Publishing Group
Schlagworte:	13/100 13/51 38/111 38/47 38/88 38/91 631/136/2086 631/532/2064 631/532/2117 631/80/474/2085 Analysis Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Blastocyst - cytology Blastocyst - enzymology Cancer Research Cell Biology Cell culture Cell regulation Cullin Proteins - metabolism Deoxyribonucleic acid Developmental Biology DNA DNA Methylation Embryo cells Embryonic stem cells Embryonic Stem Cells - enzymology Embryos Epigenesis, Genetic Epigenetic inheritance Gene expression Gene Expression Regulation, Developmental Ground state HEK293 Cells Humans Immortalization In vitro methods and tests Life Sciences Locks Mice, Inbred C57BL Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Phenotype Pluripotency Pluripotent Stem Cells - enzymology Proteasome Endopeptidase Complex - metabolism Proteasomes Protein Interaction Domains and Motifs Protein Stability Proteolysis RNA Interference Stem Cells Time Factors Transcriptome Transfection Ubiquitin-proteasome system Switzerland
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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