Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly
The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegen...
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| Vydáno v: | Frontiers in neuroscience Ročník 15; s. 711898 |
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Frontiers Media S.A
19.08.2021
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| ISSN: | 1662-453X, 1662-4548, 1662-453X |
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| Abstract | The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies with reliable ASL sequences. Generally, pseudo-continuous ASL (pCASL) is preferred because of its larger signal-to-noise ratio (SNR) compared to pulsed ASL (PASL) techniques. Available pCASL versions differ regarding their feature details. To date only little is known about the reliability and reproducibility of CBF and ATT measures obtained with the innovative Hadamard encoded pCASL variant, especially if applied on participants in old age. Therefore, we investigated an in-house developed Hadamard encoded pCASL sequence on a group of healthy elderly at two different 3 Tesla Siemens MRI systems (Skyra and mMR Biograph) and evaluated CBF and ATT reliability and reproducibility for several regions-of-interests (ROI). Calculated within-subject coefficients of variation (wsCV) demonstrated an excellent reliability of perfusion measures, whereas ATT appeared to be even more reliable than CBF [e.g., wsCV(CBF) = 2.9% vs. wsCV(ATT) = 2.3% for a gray matter (GM) ROI on Skyra system]. Additionally, a substantial agreement of perfusion values acquired on both MRI systems with an inter-session interval of 78 ± 17.6 days was shown by high corresponding intra-class correlation (ICC) coefficients [e.g., ICC(CBF) = 0.704 and ICC(ATT) = 0.754 for a GM ROI]. The usability of this novel Hadamard encoded pCASL sequence might improve future follow-up perfusion studies of the aging and/or diseased brain. |
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| AbstractList | The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies with reliable ASL sequences. Generally, pseudo-continuous ASL (pCASL) is preferred because of its larger signal-to-noise ratio (SNR) compared to pulsed ASL (PASL) techniques. Available pCASL versions differ regarding their feature details. To date only little is known about the reliability and reproducibility of CBF and ATT measures obtained with the innovative Hadamard encoded pCASL variant, especially if applied on participants in old age. Therefore, we investigated an in-house developed Hadamard encoded pCASL sequence on a group of healthy elderly at two different 3 Tesla Siemens MRI systems (Skyra and mMR Biograph) and evaluated CBF and ATT reliability and reproducibility for several regions-of-interests (ROI). Calculated within-subject coefficients of variation (wsCV) demonstrated an excellent reliability of perfusion measures, whereas ATT appeared to be even more reliable than CBF [e.g., wsCV(CBF) = 2.9% vs. wsCV(ATT) = 2.3% for a gray matter (GM) ROI on Skyra system]. Additionally, a substantial agreement of perfusion values acquired on both MRI systems with an inter-session interval of 78 ± 17.6 days was shown by high corresponding intra-class correlation (ICC) coefficients [e.g., ICC(CBF) = 0.704 and ICC(ATT) = 0.754 for a GM ROI]. The usability of this novel Hadamard encoded pCASL sequence might improve future follow-up perfusion studies of the aging and/or diseased brain. The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies with reliable ASL sequences. Generally, pseudo-continuous ASL (pCASL) is preferred because of its larger signal-to-noise ratio (SNR) compared to pulsed ASL (PASL) techniques. Available pCASL versions differ regarding their feature details. To date only little is known about the reliability and reproducibility of CBF and ATT measures obtained with the innovative Hadamard encoded pCASL variant, especially if applied on participants in old age. Therefore, we investigated an in-house developed Hadamard encoded pCASL sequence on a group of healthy elderly at two different 3 Tesla Siemens MRI systems (Skyra and mMR Biograph) and evaluated CBF and ATT reliability and reproducibility for several regions-of-interests (ROI). Calculated within-subject coefficients of variation (wsCV) demonstrated an excellent reliability of perfusion measures, whereas ATT appeared to be even more reliable than CBF [e.g., wsCV(CBF) = 2.9% vs. wsCV(ATT) = 2.3% for a gray matter (GM) ROI on Skyra system]. Additionally, a substantial agreement of perfusion values acquired on both MRI systems with an inter-session interval of 78 ± 17.6 days was shown by high corresponding intra-class correlation (ICC) coefficients [e.g., ICC(CBF) = 0.704 and ICC(ATT) = 0.754 for a GM ROI]. The usability of this novel Hadamard encoded pCASL sequence might improve future follow-up perfusion studies of the aging and/or diseased brain.The perfusion parameters cerebral blood flow (CBF) and arterial transit time (ATT) measured with arterial spin labeling (ASL) magnetic resonance imaging (MRI) provide valuable essentials to assess the integrity of cerebral tissue. Brain perfusion changes, due to aging, an intervention, or neurodegenerative diseases for example, could be investigated in longitudinal ASL studies with reliable ASL sequences. Generally, pseudo-continuous ASL (pCASL) is preferred because of its larger signal-to-noise ratio (SNR) compared to pulsed ASL (PASL) techniques. Available pCASL versions differ regarding their feature details. To date only little is known about the reliability and reproducibility of CBF and ATT measures obtained with the innovative Hadamard encoded pCASL variant, especially if applied on participants in old age. Therefore, we investigated an in-house developed Hadamard encoded pCASL sequence on a group of healthy elderly at two different 3 Tesla Siemens MRI systems (Skyra and mMR Biograph) and evaluated CBF and ATT reliability and reproducibility for several regions-of-interests (ROI). Calculated within-subject coefficients of variation (wsCV) demonstrated an excellent reliability of perfusion measures, whereas ATT appeared to be even more reliable than CBF [e.g., wsCV(CBF) = 2.9% vs. wsCV(ATT) = 2.3% for a gray matter (GM) ROI on Skyra system]. Additionally, a substantial agreement of perfusion values acquired on both MRI systems with an inter-session interval of 78 ± 17.6 days was shown by high corresponding intra-class correlation (ICC) coefficients [e.g., ICC(CBF) = 0.704 and ICC(ATT) = 0.754 for a GM ROI]. The usability of this novel Hadamard encoded pCASL sequence might improve future follow-up perfusion studies of the aging and/or diseased brain. |
| Author | Stöcker, Tony Neumann, Katja Günther, Matthias Schidlowski, Martin Düzel, Emrah |
| AuthorAffiliation | 3 Department of Epileptology, University of Bonn Medical Center , Bonn , Germany 4 Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany 7 Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg , Magdeburg , Germany 2 German Center for Neurodegenerative Diseases (DZNE) , Bonn , Germany 9 Center for Behavioral Brain Science , Magdeburg , Germany 8 Institute of Cognitive Neuroscience, University College London , London , United Kingdom 1 German Center for Neurodegenerative Diseases (DZNE) , Magdeburg , Germany 6 Department for Physics and Astronomy, University of Bonn , Bonn , Germany 5 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany |
| AuthorAffiliation_xml | – name: 6 Department for Physics and Astronomy, University of Bonn , Bonn , Germany – name: 2 German Center for Neurodegenerative Diseases (DZNE) , Bonn , Germany – name: 7 Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University Magdeburg , Magdeburg , Germany – name: 9 Center for Behavioral Brain Science , Magdeburg , Germany – name: 1 German Center for Neurodegenerative Diseases (DZNE) , Magdeburg , Germany – name: 8 Institute of Cognitive Neuroscience, University College London , London , United Kingdom – name: 4 Fraunhofer Institute for Digital Medicine MEVIS , Bremen , Germany – name: 5 MR-Imaging and Spectroscopy, University of Bremen , Bremen , Germany – name: 3 Department of Epileptology, University of Bonn Medical Center , Bonn , Germany |
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| CitedBy_id | crossref_primary_10_1016_j_diii_2024_01_006 crossref_primary_10_1002_ana_27061 crossref_primary_10_1002_jmri_28634 crossref_primary_10_1002_mrm_30091 crossref_primary_10_1016_j_neuroimage_2025_121426 crossref_primary_10_1111_sjos_12740 |
| Cites_doi | 10.1016/j.neuroimage.2008.12.027 10.3389/fnins.2021.627627 10.1152/physrev.1959.39.2.183 10.1038/jcbfm.2013.161 10.1007/s10334-014-0480-1 10.1002/jmri.22345 10.1177/0271678x17713434 10.1002/mrm.20023 10.1002/jmri.25367 10.1002/mrm.1910400303 10.1002/jmri.25834 10.1016/j.jcm.2016.02.012 10.1002/mrm.1910150117 10.1038/jcbfm.2014.81 10.1002/mrm.20580 10.1002/mrm.21790 10.1016/j.neuroimage.2021.117807 10.1109/tsp.2008.2005752 10.1016/j.neuroimage.2011.09.015 10.2307/2529310 10.1371/journal.pone.0164112 10.1016/j.neuroimage.2011.02.046 10.1002/hbm.24451 10.1073/pnas.89.1.212 10.1002/mrm.1910400308 10.1002/mrm.22320 10.1002/mrm.23286 10.1002/mrm.21420 10.1109/42.906424 10.1016/j.neuroimage.2004.07.051 10.1002/mrm.22641 10.1002/hbm.23732 10.1002/mrm.27226 10.1093/cercor/bhq224 10.1002/mrm.22256 10.1002/mrm.28839 10.1002/mrm.25197 10.1006/nimg.2002.1132 10.1097/01.rli.0000084890.57197.54 10.1002/jmri.27007 10.1177/0271678x16683690 10.1152/jappl.1954.6.12.731 10.1371/journal.pone.0183762 |
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| Copyright | Copyright © 2021 Neumann, Schidlowski, Günther, Stöcker and Düzel. Copyright © 2021 Neumann, Schidlowski, Günther, Stöcker and Düzel. 2021 Neumann, Schidlowski, Günther, Stöcker and Düzel |
| Copyright_xml | – notice: Copyright © 2021 Neumann, Schidlowski, Günther, Stöcker and Düzel. – notice: Copyright © 2021 Neumann, Schidlowski, Günther, Stöcker and Düzel. 2021 Neumann, Schidlowski, Günther, Stöcker and Düzel |
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| Title | Reliability and Reproducibility of Hadamard Encoded Pseudo-Continuous Arterial Spin Labeling in Healthy Elderly |
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