Genomic and phylogenetic characterization of Brazilian yellow fever virus strains

Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogeneti...

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Vydané v:Journal of virology Ročník 86; číslo 24; s. 13263
Hlavní autori: Nunes, Marcio R T, Palacios, Gustavo, Cardoso, Jedson F, Martins, Livia C, Sousa, Jr, Edivaldo C, de Lima, Clayton P S, Medeiros, Daniele B A, Savji, Nazir, Desai, Aaloki, Rodrigues, Sueli G, Carvalho, Valeria L, Lipkin, W Ian, Vasconcelos, Pedro F C
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.12.2012
Predmet:
Base Sequence
Brazil
DNA Primers
Genome, Viral
Glycosylation
Phylogeny
Polymerase Chain Reaction
Yellow fever virus - classification
Yellow fever virus - genetics
Brazil
ISSN:1098-5514, 1098-5514
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Shrnutí:Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus complete genomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3' noncoding region (3'NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findings suggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1098-5514
1098-5514
DOI:10.1128/JVI.00565-12