Detection and localization of early- and late-stage cancers using platelet RNA

Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show...

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Veröffentlicht in:Cancer cell Jg. 40; H. 9; S. 999
Hauptverfasser: In 't Veld, Sjors G J G, Arkani, Mohammad, Post, Edward, Antunes-Ferreira, Mafalda, D'Ambrosi, Silvia, Vessies, Daan C L, Vermunt, Lisa, Vancura, Adrienne, Muller, Mirte, Niemeijer, Anna-Larissa N, Tannous, Jihane, Meijer, Laura L, Le Large, Tessa Y S, Mantini, Giulia, Wondergem, Niels E, Heinhuis, Kimberley M, van Wilpe, Sandra, Smits, A Josien, Drees, Esther E E, Roos, Eva, Leurs, Cyra E, Tjon Kon Fat, Lee-Ann, van der Lelij, Ewoud J, Dwarshuis, Govert, Kamphuis, Maarten J, Visser, Lisanne E, Harting, Romee, Gregory, Annemijn, Schweiger, Markus W, Wedekind, Laurine E, Ramaker, Jip, Zwaan, Kenn, Verschueren, Heleen, Bahce, Idris, de Langen, Adrianus J, Smit, Egbert F, van den Heuvel, Michel M, Hartemink, Koen J, Kuijpers, Marijke J E, Oude Egbrink, Mirjam G A, Griffioen, Arjan W, Rossel, Rafael, Hiltermann, T Jeroen N, Lee-Lewandrowski, Elizabeth, Lewandrowski, Kent B, De Witt Hamer, Philip C, Kouwenhoven, Mathilde, Reijneveld, Jaap C, Leenders, William P J, Hoeben, Ann, Verdonck-de Leeuw, Irma M, Leemans, C René, Baatenburg de Jong, Robert J, Terhaard, Chris H J, Takes, Robert P, Langendijk, Johannes A, de Jager, Saskia C, Kraaijeveld, Adriaan O, Pasterkamp, Gerard, Smits, Minke, Schalken, Jack A, Łapińska-Szumczyk, Sylwia, Łojkowska, Anna, Żaczek, Anna J, Lokhorst, Henk, van de Donk, Niels W C J, Nijhof, Inger, Prins, Henk-Jan, Zijlstra, Josée M, Idema, Sander, Baayen, Johannes C, Teunissen, Charlotte E, Killestein, Joep, Besselink, Marc G, Brammen, Lindsay, Bachleitner-Hofmann, Thomas, Mateen, Farrah, Plukker, John T M, Heger, Michal, de Mast, Quirijn, Lisman, Ton, Pegtel, D Michiel, Bogaard, Harm-Jan, Jassem, Jacek, Supernat, Anna, Mehra, Niven, Gerritsen, Winald, de Kroon, Cornelis D, Lok, Christianne A R, Piek, Jurgen M J, Steeghs, Neeltje, van Houdt, Winan J, Brakenhoff, Ruud H, Sonke, Gabe S, Verheul, Henk M, Giovannetti, Elisa, Kazemier, Geert, Sabrkhany, Siamack, Schuuring, Ed, Sistermans, Erik A
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 12.09.2022
Schlagworte:
Biomarkers, Tumor - genetics
Blood Platelets
Early Detection of Cancer - methods
Humans
Neoplasms - diagnosis
Neoplasms - genetics
RNA - genetics
blood platelets
RNA
cancer
early detection
blood
TEP
liquid biopsy
ISSN:1878-3686, 1878-3686
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Zusammenfassung:Cancer patients benefit from early tumor detection since treatment outcomes are more favorable for less advanced cancers. Platelets are involved in cancer progression and are considered a promising biosource for cancer detection, as they alter their RNA content upon local and systemic cues. We show that tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types. With 99% specificity in asymptomatic controls, thromboSeq correctly detected the presence of cancer in two-thirds of 1,096 blood samples from stage I-IV cancer patients and in half of 352 stage I-III tumors. Symptomatic controls, including inflammatory and cardiovascular diseases, and benign tumors had increased false-positive test results with an average specificity of 78%. Moreover, thromboSeq determined the tumor site of origin in five different tumor types correctly in over 80% of the cancer patients. These results highlight the potential properties of TEP-derived RNA panels to supplement current approaches for blood-based cancer screening.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1878-3686
1878-3686
DOI:10.1016/j.ccell.2022.08.006