Predominance of hepatitis B virus genotype C among Karens, the 'old settlers' of Andaman and Nicobar Islands, India

The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by...

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Bibliographic Details
Published in:Archives of virology Vol. 152; no. 6; pp. 1223 - 1228
Main Authors: Datta, S, Chandra, P. K, Banerjee, A, Chakravarty, R, Murhekar, K. M, Murhekar, M. V
Format: Journal Article
Language:English
Published: Wien Vienna : Springer-Verlag 01.06.2007
New York, NY Springer
Springer Nature B.V
Subjects:
Adolescent
Adult
Andaman and Nicobar Islands
Biological and medical sciences
Burma
classification
disease severity
DNA, Viral
DNA, Viral - genetics
Emigration and Immigration
epidemiological studies
Epidemiology
Ethnic Groups
Ethnicity
ethnology
Evolution, Molecular
Female
Fundamental and applied biological sciences. Psychology
Genes, Viral
genetics
genotype
Genotype & phenotype
genotyping
Hepatitis B
Hepatitis B - virology
Hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Humans
India
Infections
isolation & purification
Male
Medical research
Microbiology
Middle Aged
Miscellaneous
Molecular Sequence Data
Mutation
Myanmar
Myanmar - ethnology
people
Phylogenetics
Phylogeny
Polymerase chain reaction
Virology
Indian Ocean Islands
Andaman and Nicobar
Asia
India
Myanmar
East Asia
Myanmar (Burma)
West Bengal India
Nicobar Islands
Burma
Andaman and Nicobar Islands
Virus
Hepadnaviridae
Orthohepadnavirus
Genotype
Hepatitis B virus
Flaviviridae
Hepatitis C virus
Hepacivirus
ISSN:0304-8608, 1432-8798
Online Access:Get full text
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Summary:The Karens, or 'old settlers', migrated from Myanmar to Andaman and Nicobar islands 80 years ago. A high HBV exposure rate among them has been reported. A study of 34 HBsAg carriers was done to investigate the origin of HBV infection among the Karens. RFLP-based genotyping was confirmed by sequencing and phylogenetic analysis. The predominance of HBV/C1/Cs suggests that they carried HBV during their migration, retained it, and in addition, acquired HBV/D2 from the people of mainland India. The reported association of HBV genotype C with disease severity thus warrants further epidemiological investigations among them and on possible spread among neighboring settlers.
Bibliography:http://dx.doi.org/10.1007/s00705-006-0910-0
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ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-006-0910-0