The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons

Neurotoxicity of human immunodeficiency virus-1 (HIV) includes synaptic simplification and neuronal apoptosis. However, the mechanisms of HIV-associated neurotoxicity remain unclear, thus precluding an effective treatment of the neurological complications. The present study was undertaken to charact...

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Bibliographic Details
Published in:	Neurotoxicity research Vol. 29; no. 4; pp. 583 - 593
Main Authors:	Avdoshina, Valeria, Fields, Jerel Adam, Castellano, Paul, Dedoni, Simona, Palchik, Guillermo, Trejo, Margarita, Adame, Anthony, Rockenstein, Edward, Eugenin, Eliseo, Masliah, Eliezer, Mocchetti, Italo
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.05.2016
Subjects:	Adult Animals Biomedical and Life Sciences Biomedicine Cell Biology Cells, Cultured Cohort Studies Electron Microscope Tomography Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - toxicity HIV Infections - complications HIV Infections - pathology Humans Mice Mice, Transgenic Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Middle Aged Mitochondria - pathology Mitochondria - ultrastructure Mitochondrial Dynamics Neurobiology Neurochemistry Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neurons - ultrastructure Neurosciences Neurotoxicity Syndromes - genetics Neurotoxicity Syndromes - pathology Original Article Pharmacology/Toxicology Rats Smegmamorpha Time Factors Mitochondrial respiration HIVE Oxygen consumption Tom 20 Gp120ADA Fis-1
ISSN:	1029-8428, 1476-3524
Online Access:	Get full text
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