Effects of low-calorie and different weight-maintenance diets on IgG glycome composition

Obesity-induced inflammation activates the adaptive immune system by altering immunoglobulin G (IgG) glycosylation in a way to produce more proinflammatory antibodies. The IgG glycome has already been well studied, and its alterations are correlated with a high body mass index (BMI) and central adip...

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Veröffentlicht in:Frontiers in immunology Jg. 13; S. 995186
Hauptverfasser: Deriš, Helena, Tominac, Petra, Vučković, Frano, Briški, Nina, Astrup, Arne, Blaak, Ellen E., Lauc, Gordan, Gudelj, Ivan
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Frontiers Media S.A 21.09.2022
Schlagworte:
calorie reduction
glycosylation
healthy diet
IgG
Immunology
weight maintenance
ISSN:1664-3224, 1664-3224
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Zusammenfassung:Obesity-induced inflammation activates the adaptive immune system by altering immunoglobulin G (IgG) glycosylation in a way to produce more proinflammatory antibodies. The IgG glycome has already been well studied, and its alterations are correlated with a high body mass index (BMI) and central adiposity. Still, the IgG N-glycome susceptibility to different dietary regimes for weight control after the initial weight loss has not been studied. To explore changes in IgG glycosylation induced by weight loss and subsequent weight-maintenance diets, we analyzed 1,850 IgG glycomes from subjects in a dietary intervention Diogenes study. In this study, participants followed a low-calorie diet (LCD) providing 800 kcal/d for 8 weeks, followed by one of five weight-maintenance diets over a 6-month period. The most significant alteration of the IgG N-glycome was present 8 weeks after the subjects underwent an LCD, a statistically significant decrease of agalactosylated and the increase of sialylated N glycans. In the follow-up period, the increase in glycans with bisecting GlcNAc and the decrease in sialylated glycans were observed. Those changes were present regardless of the diet type, and we did not observe significant changes between different diets. However, it should be noted that in all five diet groups, there were individuals who prominently altered their IgG glycome composition in either proinflammatory or anti-inflammatory directions.
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This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
Reviewed by: Yong Gu, Nanjing Medical University, China; Andras Guttman, University of Pannonia, Hungary
Edited by: Wei Wang, Edith Cowan University, Australia
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.995186