Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

Introduction We describe the use of bacteriophage therapy in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation. Hospital Course The patient developed multidrug resistant (MDR) Pseudomonas aeruginosa pneumonia, persistent respiratory failure, and colistin-induced renal failure....

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Veröffentlicht in:Infection Jg. 47; H. 4; S. 665 - 668
Hauptverfasser: Law, Nancy, Logan, Cathy, Yung, Gordon, Furr, Carrie-Lynn Langlais, Lehman, Susan M., Morales, Sandra, Rosas, Francisco, Gaidamaka, Alexander, Bilinsky, Igor, Grint, Paul, Schooley, Robert T., Aslam, Saima
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2019
Springer Nature B.V
Schlagworte:
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Case Report
Colistin
Cystic fibrosis
Drug resistance
Family Medicine
General Practice
Infectious Diseases
Internal Medicine
Intravenous administration
Lung transplantation
Lung transplants
Medicine
Medicine & Public Health
Multidrug resistance
Multidrug resistant organisms
Patients
Pneumonia
Pseudomonas aeruginosa
Renal failure
Respiratory failure
Therapy
Transplantation
Multidrug-resistant
Antimicrobial
Cystic fibrosis
Antibiotic
Bacteriophage therapy
Lung transplant
Multidrug-resistant Pseudomonas aeruginosa
ISSN:0300-8126, 1439-0973, 1439-0973
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Zusammenfassung:Introduction We describe the use of bacteriophage therapy in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation. Hospital Course The patient developed multidrug resistant (MDR) Pseudomonas aeruginosa pneumonia, persistent respiratory failure, and colistin-induced renal failure. We describe the use of intravenous bacteriophage therapy (BT) along with systemic antibiotics in this patient, lack of adverse events, and clinical resolution of infection with this approach. She did not have recurrence of pseudomonal pneumonia and CF exacerbation within 100 days following the end of BT and underwent successful bilateral lung transplantation 9 months later. Conclusion Given the concern for MDR P. aeruginosa infections in CF patients, BT may offer a viable anti-infective adjunct to traditional antibiotic therapy.
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ISSN:0300-8126
1439-0973
1439-0973
DOI:10.1007/s15010-019-01319-0