Neutralization of BA.4–BA.5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent Vaccine

Participants who had received three doses of BNT162b2 vaccine received either a fourth dose or a bivalent vaccine containing BA.4–BA.5 mRNA; the latter group had higher neutralization against omicron variants.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 388; no. 9; pp. 854 - 857
Main Authors: Zou, Jing, Kurhade, Chaitanya, Patel, Sohil, Kitchin, Nicholas, Tompkins, Kristin, Cutler, Mark, Cooper, David, Yang, Qi, Cai, Hui, Muik, Alexander, Zhang, Ying, Lee, Dung-Yang, Şahin, Ugur, Anderson, Annaliesa S., Gruber, William C., Xie, Xuping, Swanson, Kena A., Shi, Pei-Yong
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 02.03.2023
Subjects:
Antibodies
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Confidence intervals
Coronavirus
Coronaviruses
Correspondence
COVID-19 - immunology
COVID-19 - therapy
COVID-19 - virology
COVID-19 Vaccines - immunology
COVID-19 Vaccines - therapeutic use
Humans
Infections
Infectious Disease
mRNA
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Vaccines
Vaccines, Combined - immunology
Vaccines, Combined - therapeutic use
Viral Infections
Viruses
United States > US
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:Participants who had received three doses of BNT162b2 vaccine received either a fourth dose or a bivalent vaccine containing BA.4–BA.5 mRNA; the latter group had higher neutralization against omicron variants.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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Drs. Zou and Kurhade contributed equally to this letter.
ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMc2214916