The role of thioredoxin system in cancer: strategy for cancer therapy

Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and...

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Vydáno v:	Cancer chemotherapy and pharmacology Ročník 84; číslo 3; s. 453 - 470
Hlavní autoři:	Jia, Jin-Jing, Geng, Wen-Shuo, Wang, Zhan-Qi, Chen, Lei, Zeng, Xian-Si
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019 Springer Nature B.V
Témata:	Antineoplastic Agents - therapeutic use Antitumor activity Cancer Cancer Research Cancer therapies Cytotoxicity Humans Medicine Medicine & Public Health Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Oncology Pharmacology/Toxicology Public health Reductase Review Article Thioredoxin Thioredoxins - antagonists & inhibitors Redox Inhibitor Thioredoxin system Combined therapy Cancer
ISSN:	0344-5704, 1432-0843, 1432-0843
On-line přístup:	Získat plný text
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