Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis

Atopic dermatitis (AD) is an inflammatory skin condition with a childhood prevalence of up to 25%. Microbial dysbiosis is characteristic of AD, with Staphylococcus aureus the most frequent pathogen associated with disease flares and increasingly implicated in disease pathogenesis. Therapeutics to mi...

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Vydáno v:JCI insight Ročník 9; číslo 9
Hlavní autoři: Clowry, Julianne, Dempsey, Daniel J., Claxton, Tracey J., Towell, Aisling M., Turley, Mary B., Sutton, Martin, Geoghegan, Joan A., Kezic, Sanja, Jakasa, Ivone, White, Arthur, Irvine, Alan D., McLoughlin, Rachel M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Society for Clinical Investigation 08.05.2024
American Society for Clinical investigation
Témata:
Antibiotics
Antigens
Antigens, Differentiation, T-Lymphocyte
Atopic dermatitis
Bayes Theorem
Bayesian analysis
CD4 antigen
CD8 antigen
CD8-Positive T-Lymphocytes - immunology
Chemokine CXCL10 - immunology
Chemokine CXCL10 - metabolism
Chemokines
Child
Child, Preschool
Children
Dermatitis
Dermatitis, Atopic - immunology
Dermatitis, Atopic - microbiology
Dermatology
Disease
Dysbacteriosis
Female
Helper cells
Humans
Immune response
Immunity (Disease)
Immunological memory
Immunology
Interleukin-10 - immunology
Interleukin-10 - metabolism
Intraepithelial Lymphocytes - immunology
Lymphocytes
Lymphocytes T
Male
Membrane Glycoproteins
Memory cells
Pathogenesis
Pathogens
Patients
Pediatrics
Skin - immunology
Skin - microbiology
Skin - pathology
Skin diseases
Staphylococcal Skin Infections - immunology
Staphylococcal Skin Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - immunology
Staphylococcus infections
Th1 Cells - immunology
Th17 Cells - immunology
Th2 Cells - immunology
Vaccines
Dermatology
Adaptive immunity
Immunology
ISSN:2379-3708, 2379-3708
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Popis
Shrnutí:Atopic dermatitis (AD) is an inflammatory skin condition with a childhood prevalence of up to 25%. Microbial dysbiosis is characteristic of AD, with Staphylococcus aureus the most frequent pathogen associated with disease flares and increasingly implicated in disease pathogenesis. Therapeutics to mitigate the effects of S. aureus have had limited efficacy and S. aureus-associated temporal disease flares are synonymous with AD. An alternative approach is an anti-S. aureus vaccine, tailored to AD. Experimental vaccines have highlighted the importance of T cells in conferring protective anti-S. aureus responses; however, correlates of T cell immunity against S. aureus in AD have not been identified. We identify a systemic and cutaneous immunological signature associated with S. aureus skin infection (ADS.aureus) in a pediatric AD cohort, using a combined Bayesian multinomial analysis. ADS.aureus was most highly associated with elevated cutaneous chemokines IP10 and TARC, which preferentially direct Th1 and Th2 cells to skin. Systemic CD4+ and CD8+ T cells, except for Th2 cells, were suppressed in ADS.aureus, particularly circulating Th1, memory IL-10+ T cells, and skin-homing memory Th17 cells. Systemic γδ T cell expansion in ADS.aureus was also observed. This study suggests that augmentation of protective T cell subsets is a potential therapeutic strategy in the management of S. aureus in AD.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2379-3708
2379-3708
DOI:10.1172/jci.insight.178789