Microbiota succession throughout life from the cradle to the grave

Associations between age and the human microbiota are robust and reproducible. The microbial composition at several body sites can predict human chronological age relatively accurately. Although it is largely unknown why specific microorganisms are more abundant at certain ages, human microbiota res...

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Veröffentlicht in:Nature reviews. Microbiology Jg. 20; H. 12; S. 707 - 720
Hauptverfasser: Martino, Cameron, Dilmore, Amanda Hazel, Burcham, Zachary M, Metcalf, Jessica L, Jeste, Dilip, Knight, Rob
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Nature Publishing Group 01.12.2022
Schlagworte:
Age
Antibiotics
Bacteria - genetics
Birth
Death
Ecological succession
Fungi
Humans
Infant, Newborn
Longitudinal studies
Microbiota
Microorganisms
Robustness
Statistical analysis
ISSN:1740-1526, 1740-1534, 1740-1534
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Zusammenfassung:Associations between age and the human microbiota are robust and reproducible. The microbial composition at several body sites can predict human chronological age relatively accurately. Although it is largely unknown why specific microorganisms are more abundant at certain ages, human microbiota research has elucidated a series of microbial community transformations that occur between birth and death. In this Review, we explore microbial succession in the healthy human microbiota from the cradle to the grave. We discuss the stages from primary succession at birth, to disruptions by disease or antibiotic use, to microbial expansion at death. We address how these successions differ by body site and by domain (bacteria, fungi or viruses). We also review experimental tools that microbiota researchers use to conduct this work. Finally, we discuss future directions for studying the microbiota's relationship with age, including designing consistent, well-powered, longitudinal studies, performing robust statistical analyses and improving characterization of non-bacterial microorganisms.
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ISSN:1740-1526
1740-1534
1740-1534
DOI:10.1038/s41579-022-00768-z