Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy

Identifying the functions of human immunodeficiency virus (HIV)-specific CD8+ T cells that are not merely modulated by the level of virus but clearly distinguish patients with immune control from those without such control is of paramount importance. Features of the HIV-specific CD8+ T-cell response...

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Veröffentlicht in:	Journal of virology Jg. 83; H. 22; S. 11876
Hauptverfasser:	Migueles, Stephen A, Weeks, Kristin A, Nou, Eric, Berkley, Amy M, Rood, Julia E, Osborne, Christine M, Hallahan, Claire W, Cogliano-Shutta, Nancy A, Metcalf, Julia A, McLaughlin, Mary, Kwan, Richard, Mican, JoAnn M, Davey, Jr, Richard T, Connors, Mark
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.11.2009
Schlagworte:	Adolescent Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use CD4 Lymphocyte Count CD4-CD8 Ratio CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - physiology CD8-Positive T-Lymphocytes - virology Cell Transformation, Viral - drug effects Cell Transformation, Viral - immunology Child Child, Preschool Disease Progression Flow Cytometry HIV Infections - drug therapy HIV Infections - immunology Humans Lymphocyte Activation - immunology RNA, Viral - metabolism Young Adult
ISSN:	1098-5514, 1098-5514
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