The roles of intrinsically disordered proteins in neurodegeneration

Neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease share a common pathological hallmark: the accumulation of misfolded proteins, particularly involving intrinsically disordered proteins (IDPs) like TDP-4...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1869; no. 4; p. 130772
Main Authors:	Utami, Kagistia Hana, Morimoto, Satoru, Mitsukura, Yasue, Okano, Hideyuki
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.04.2025
Subjects:	Aggregation alpha-Synuclein - metabolism Alzheimer disease amyotrophic lateral sclerosis Animals Autophagy Chaperone drugs Humans Intrinsically disordered proteins Intrinsically Disordered Proteins - metabolism Liquid-liquid phase separation Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Parkinson disease proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism Proteostasis separation therapeutics toxicity Aggregation Proteostasis Neurodegenerative diseases Intrinsically disordered proteins Chaperone Liquid-liquid phase separation Autophagy
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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