Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways

Radiotherapy causes the regression of many human tumors by increasing DNA damage, and the novel molecular mechanisms underlying the genomic instability leading to cancer progression and metastasis must be elucidated. Atypical dual-specificity phosphatase 3 (DUSP3) has been shown to down-regulate mit...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1861; no. 7; pp. 1879 - 1894
Main Authors:	Torres, Thompson E.P., Russo, Lilian C., Santos, Alexsandro, Marques, Gabriela R., Magalhaes, Yuli T., Tabassum, Sartaj, Forti, Fabio L.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.07.2017
Subjects:	apoptosis Ataxia Telangiectasia Mutated Proteins - physiology Cell Line, Tumor cell proliferation cell senescence DNA DNA Damage DNA damage response DNA Repair Dual Specificity Phosphatase 3 - antagonists & inhibitors Dual Specificity Phosphatase 3 - physiology Dual-specificity tyrosine phosphatases DUSP3/VHR Gamma radiation Gamma Rays HeLa and MeWo tumor cells Histones - analysis homologous recombination Humans ionization metastasis mitogen-activated protein kinase Mitogen-Activated Protein Kinases - metabolism neoplasm cells neoplasms Neoplasms - radiotherapy radiation resistance Radiation Tolerance radiotherapy Recombination DNA repair mechanisms small interfering RNA Recombination DNA repair mechanisms HeLa and MeWo tumor cells Dual-specificity tyrosine phosphatases DUSP3/VHR Gamma radiation DNA damage response
ISSN:	0304-4165, 1872-8006
Online Access:	Get full text
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